Recombinant Human MSH6, His-tagged

• Cat.No.: MSH6-2413H
• Product Overview: Recombinant Human MSH6 as expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: False
• Description: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
• AA Sequence: 1-400aa
• Storage: The protein is stored in PBS buffer at -20 oC. Repeated freeze-thaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: MSH6 mutS homolog 6 [ Homo sapiens (human) ]
• Official Symbol: MSH6
• Synonyms: MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; mutS homolog 6; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein
• Gene ID: 2956
• mRNA Refseq: NM_000179
• Protein Refseq: NP_000170
• MIM: 600678
• UniProt ID: P52701
• Chromosome Location: 2p16
• Pathway: BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Mismatch repair
• Function: contributes_to ADP binding; contributes_to ATPase activity; contributes_to MutLalpha complex binding