Recombinant Human metallopeptidase inhibitor 1, His-tagged

• Cat.No.: TIMP1-287H
• Product Overview: Recombinant Human TIMP-1 comprises a 184 amino acid fragment (24-207) corresponding to the mature TIMP-1 protein and is expressed inE. coliwith an aminoterminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: TIMP-1 is an inducible glycoprotein, which is synthesized by many different cell types. TIMP-1 binds in a reversible fashion to matrix metalloproteinases, with regions in the N-terminal domain binding to the MMP substrate-binding site. TIMP-1 also functions as erthyroid-potentiating activity via translocation to the nucleus and also in inhibiting apoptosis in B-cells.
• Purity: >95% by SDS-PAGE
• Form: Liquid
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ]
• Synonyms: CLGI; EPA, EPO; HCI; TIMP; Erythroid-potentiating activity; tissue inhibitor of metalloprotease 1; collagenase inhibitor; metalloprotease inhibitor 1 precursor; tissue inhibitor of metalloproteases; FLJ90373; OTTHUMP00000023214; TIMP-1; Collagenase inhibitor; Erythroid-potentiating activity; TIMP metallopeptidase inhibitor 1; erythroid potentiating activity; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor.
• Gene ID: 7076
• mRNA Refseq: NM_003254
• Protein Refseq: NP_003245
• MIM: 305370
• UniProt ID: P01033
• Chromosome Location: Xp11.3-p11.23
• Function: enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protein binding