Recombinant Human MERTK Protein, hFc-Avi tagged, Biotinylated
Cat.No. : | MERTK-03H |
Product Overview : | Biotinylated Recombinant Human MerTK (C-hFc-Avi) is produced by Human Cells. The target gene encoding Arg26-Ala499 is expressed with a C-hFc-Avi tag. |
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Species : | Human |
Source : | Human Cells |
Tag : | Avi&Fc |
Protein Length : | Arg26-Ala499 |
Description : | Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
Endotoxin : | Less than 0.1 ng/μg (1 EU/μg) |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 |
Shipping : | Ambient |
Gene Name | MERTK c-mer proto-oncogene tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol | MERTK |
Synonyms | MERTK; Mer |
Gene ID | 10461 |
mRNA Refseq | NM_006343 |
Protein Refseq | NP_006334 |
MIM | 604705 |
UniProt ID | Q12866 |
◆ Recombinant Proteins | ||
MERTK-3306R | Recombinant Rat MERTK Protein, His (Fc)-Avi-tagged | +Inquiry |
MERTK-3903H | Recombinant Human MERTK Protein (Leu587-Leu858), N-His tagged | +Inquiry |
Mertk-4035M | Recombinant Mouse Mertk Protein, Myc/DDK-tagged | +Inquiry |
Mertk-001D | Recombinant Dog MERTK protein, GST-tagged | +Inquiry |
MERTK-176M | Recombinant Mouse MERTK Protein, Fc-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
MERTK-1816MCL | Recombinant Mouse MERTK cell lysate | +Inquiry |
MERTK-484HCL | Recombinant Human MERTK cell lysate | +Inquiry |
MERTK-2888HCL | Recombinant Human MERTK cell lysate | +Inquiry |
MERTK-413MCL | Recombinant Mouse MERTK cell lysate | +Inquiry |
MERTK-001HCL | Recombinant Human MERTK cell lysate | +Inquiry |
Not For Human Consumption!
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