Recombinant Mouse Mertk Protein, hIgG&His-tagged

• Cat.No.: Mertk-23M
• Product Overview: Recombinant Mouse Mertk Protein, hIgG&His-tagged,expressed in Baculovirus.

Specification

• Description: Mer, also known as Tyrosine-protein kinase Mer, is one of the receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm. It regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells. This protein plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Mutations in this protein have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). Recombinant mouse Mer, fused to hIgG-His-tag, was expressed in insect cell and purified by using conventional chromatography techniques.
• Source: Baculovirus
• Species: Mouse
• Tag: hIgG&His
• Protein length: 19-497 aa
• Molecular Mass: 79.2 kDa
• AA Sequence: GGTAEKWEET ELDQLFSGPL PGRLPVNHRP FSAPHSSRDQ LPPPQTGRSH PAHTAAPQVT STASKLLPPV AFNHTIGHIV
  LSEHKNVKFN CSINIPNTYQ ETAGISWWKD GKELLGAHHS ITQFYPDEEG VSIIALFSIA SVQRSDNGSY FCKMKVNNRE
  IVSDPIYVEV QGLPYFIKQP ESVNVTRNTA FNLTCQAVGP PEPVNIFWVQ NSSRVNEKPE RSPSVLTVPG LTETAVFSCE
  AHNDKGLTVS KGVHINIKVI PSPPTEVHIL NSTAHSILVS WVPGFDGYSP LQNCSIQVKE ADRLSNGSVM VFNTSASPHL
  YEIQQLQALA NYSIAVSCRN EIGWSAVSPW ILASTTEGAP SVAPLNITVF LNESNNILDI RWTKPPIKRQ DGELVGYRIS
  HVWESAGTYK ELSEEVSQNG SWAQIPVQIH NATCTVRIAA ITKGGIGPFS EPVNIIIPEH SKVDYAPSST PAPGNTDSMEPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
  YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS
  DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by absorbance at 280nm)
• Storage Buffer: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
• References: Grabiec AM., et al. (2018) Eur J Immunol. 48:855-860.
  McHenry CL., et al. (2004) Invest Ophthalmol Vis Sci. 45:1456-1463.

Gene Information

• Gene Name: Mertk MER proto-oncogene tyrosine kinase [ Mus musculus (house mouse) ]
• Official Symbol: Mertk
• Synonyms: Mertk, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Eyk, Mer, nmf12, Nyk,Tyrosine-protein kinase Mer
• Gene ID: 17289
• mRNA Refseq: NM_008587
• Protein Refseq: NP_032613
• UniProt ID: Q60805