Recombinant Human MC1R Protein, Full Length, N-GST tagged

• Cat.No.: MC1R-3087HFL
• Product Overview: Human MC1R full-length ORF (NP_002377.3, 1 a.a. - 317 a.a.) recombinant protein with GST tag at N-terminal was expressed in Wheat Germ (in vitro).

Specification

• Description: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
• Source: Wheat Germ (in vitro)
• Species: Human
• Tag: GST
• Protein length: Full Length
• Molecular Mass: 61.1 kDa
• AA Sequence: MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSTVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Quality Control Test: 12.5% SDS-PAGE Stained with Coomassie Blue.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) [ Homo sapiens (human) ]
• Official Symbol: MC1R
• Synonyms: MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor; MSH R; MC1-R; melanotropin receptor; CMM5; MSH-R; SHEP2; MGC14337
• Gene ID: 4157
• mRNA Refseq: NM_002386
• Protein Refseq: NP_002377
• MIM: 155555
• UniProt ID: Q01726