MC1R

  • Official Full Name

    melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

  • Overview

    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

  • Synonyms

    MC1R;melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor);melanocyte-stimulating hormone receptor;MSH R;MC1-R;Melanocortin 1 receptor;Melanocortin receptor 1;MSH-R;MSHR;MSHR_HUMAN;melanotropin receptor;CMM5;SHEP2

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • Vulpes vulpes (Red fox)
  • Leontopithecus rosalia (Golden lion tamarin)
  • Mandrillus sphinx (Mandrill) (Papio sphinx)
  • Trachypithecus auratus (Javan langur)
  • Eulemur fulvus fulvus (Brown lemur)
  • Felis catus
  • Macaca sylvanus (Barbary macaque)
  • Cercopithecus neglectus (De Brazza's monkey)
  • Cervus elaphus
  • Panthera onca (Jaguar) (Felis onca)
  • Macaca mulatta
  • Saguinus fuscicollis (Brown-headed tamarin)
  • Puma yagouaroundi (Jaguarundi) (Herpailurus yagouaroundi)
  • Sheep
  • Pongo Pygmaeus
  • Cercopithecus mitis (Blue monkey)
  • Leontopithecus chrysomelas (Golden-headed lion tamarin)
  • Sus scrofa (Pig)
  • Horse
  • Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi)
  • Capreolus capreolus (Roe deer)
  • Hapalemur griseus (Gray gentle lemur) (Eastern lesser bamboo lemur)
  • Callithrix geoffroyi (Geoffroy's marmoset)
  • Pan troglodytes
  • Erythrocebus patas (Red guenon) (Cercopithecus patas)
  • Semnopithecus entellus (Hanuman langur) (Presbytis entellus)
  • Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)
  • Chaetodipus baileyi (Bailey's pocket mouse) (Perognathus baileyi)
  • Alouatta pigra (Guatemalan howler monkey) (Mexican black howler monkey)
  • Alouatta seniculus (Red howler monkey)
  • Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata)
  • Callimico goeldii (Goeldi's marmoset)
  • Allenopithecus nigroviridis (Allen's swamp monkey)
  • Mammuthus primigenius (Siberian woolly mammoth)
  • Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)
  • Presbytis comata (Grizzled leaf monkey)
  • Saguinus imperator (Emperor tamarin)
  • Dog
  • Loris tardigradus (Slender loris)
  • Goat
  • Rangifer tarandus (Reindeer) (Cervus tarandus)
  • Saguinus oedipus (Cotton-top tamarin)
  • Leontopithecus chrysopygus (Golden-rumped lion tamarin) (Leontopithecus rosalia chrysopygus)
  • Dama dama (Fallow deer) (Cervus dama)
  • Varecia variegata rubra (Red ruffed lemur) (Varecia rubra)
  • Varecia variegata variegata (Black and white ruffed lemur)
  • Lemur catta (Ring-tailed lemur)
  • Alces alces alces (European moose) (Elk)
  • Vulpes lagopus (Arctic fox) (Alopex lagopus)
  • Callithrix pygmaea (Pygmy marmoset) (Cebuella pygmaea)
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Ovibos moschatus (Muskox)
  • Hylobates lar (Common gibbon) (White-handed gibbon)
  • Galago senegalensis (Northern lesser bushbaby) (Senegal bushbaby)
  • Ateles paniscus (Black spider monkey) (Red-faced black spider monkey)
  • Bovine
  • Papio hamadryas (Hamadryas baboon)
  • Callithrix argentata (Silvery marmoset) (Mico argentatus)
  • Cebus albifrons (White-fronted capuchin)
  • Nomascus concolor (Black crested gibbon) (Hylobates concolor)
  • Chaetodipus penicillatus (Desert pocket mouse) (Perognathus penicillatus)
  • Alouatta palliata (Mantled howler monkey)
  • Saguinus midas (Midas tamarin) (Golden-handed tamarin)
  • Saimiri oerstedii (Central American squirrel monkey)
  • Chlorocebus Aethiops
  • Cercopithecus diana (Diana monkey)
  • Trachypithecus obscurus (Dusky leaf-monkey) (Presbytis obscura)
  • Alouatta sara (Bolivian red howler monkey)
  • Macaca silenus (Lion-tailed macaque)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Mus musculus
  • Alouatta caraya (Black howler monkey)
  • Papio anubis (Olive baboon)
  • Macaca nigra (Celebes black macaque) (Crested black macaque)
  • Hylobates muelleri (Mueller's Bornean gibbon)
  • Saguinus geoffroyi (Geoffroy's tamarin)
  • Macaca nemestrina (Pig-tailed macaque)
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • E.coli
  • Non
  • His
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
MC1R-29451TH Recombinant Human MC1R Wheat Germ Human Non 100 amino acids
MC1R-3109C Recombinant Chicken MC1R Mammalian Cells Chicken His
MC1R-9612Z Recombinant Zebrafish MC1R Mammalian Cells Zebrafish His
MC1R-4434HCL Recombinant Human MC1R 293 Cell Lysate HEK293 Human Non
Mc1r-0183M Recombinant Mouse Mc1r Full Length Transmembrane Protein(1-315aa), His-tagged(VLPs) HEK293 Mouse His Full L. 1-315aa
MC1R-3087HFL Recombinant Human MC1R Protein, Full Length, N-GST tagged Wheat Germ Human GST Full L. Full Length
RFL10108VF Recombinant Full Length Vulpes Vulpes Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Vulpes vulpes (Red fox) His Full L. Full Length (1-317)
RFL10130LF Recombinant Full Length Leontopithecus Rosalia Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Leontopithecus rosalia (Golden lion tamarin) His Full L. Full Length (1-318)
RFL10558MF Recombinant Full Length Mandrillus Sphinx Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Mandrillus sphinx (Mandrill) (Papio sphinx) His Full L. Full Length (1-317)
RFL10997TF Recombinant Full Length Trachypithecus Auratus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Trachypithecus auratus (Javan langur) His Full L. Full Length (1-317)
RFL1229EF Recombinant Full Length Eulemur Fulvus Fulvus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Eulemur fulvus fulvus (Brown lemur) His Full L. Full Length (1-317)
RFL14300FF Recombinant Full Length Cat Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Felis catus His Full L. Full Length (1-317)
RFL14475MF Recombinant Full Length Macaca Sylvanus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Macaca sylvanus (Barbary macaque) His Full L. Full Length (1-317)
RFL15019CF Recombinant Full Length Cercopithecus Neglectus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Cercopithecus neglectus (De Brazza's monkey) His Full L. Full Length (1-317)
RFL15327CF Recombinant Full Length Cervus Elaphus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Cervus elaphus His Full L. Full Length (1-317)
RFL15670PF Recombinant Full Length Panthera Onca Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Panthera onca (Jaguar) (Felis onca) His Full L. Full Length (1-317)
RFL15814MF Recombinant Full Length Macaca Mulatta Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Macaca mulatta His Full L. Full Length (1-317)
RFL16270SF Recombinant Full Length Saguinus Fuscicollis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Saguinus fuscicollis (Brown-headed tamarin) His Full L. Full Length (1-316)
RFL16275PF Recombinant Full Length Puma Yagouaroundi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Puma yagouaroundi (Jaguarundi) (Herpailurus yagouaroundi) His Full L. Full Length (1-317)
RFL16665OF Recombinant Full Length Sheep Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Sheep His Full L. Full Length (1-317)
RFL16912PF Recombinant Full Length Pongo Pygmaeus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Pongo Pygmaeus His Full L. Full Length (1-317)
RFL16940CF Recombinant Full Length Cercopithecus Mitis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Cercopithecus mitis (Blue monkey) His Full L. Full Length (1-317)
RFL17645LF Recombinant Full Length Leontopithecus Chrysomelas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Leontopithecus chrysomelas (Golden-headed lion tamarin) His Full L. Full Length (1-310)
RFL17659SF Recombinant Full Length Pig Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Sus scrofa (Pig) His Full L. Full Length (1-320)
RFL1765EF Recombinant Full Length Horse Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Horse His Full L. Full Length (1-317)
RFL17719TF Recombinant Full Length Trachypithecus Francoisi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi) His Full L. Full Length (1-317)
RFL17811CF Recombinant Full Length Capreolus Capreolus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Capreolus capreolus (Roe deer) His Full L. Full Length (1-317)
RFL18232HF Recombinant Full Length Hapalemur Griseus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Hapalemur griseus (Gray gentle lemur) (Eastern lesser bamboo lemur) His Full L. Full Length (1-317)
RFL1863CF Recombinant Full Length Callithrix Geoffroyi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Callithrix geoffroyi (Geoffroy's marmoset) His Full L. Full Length (1-344)
RFL18956PF Recombinant Full Length Pan Troglodytes Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Pan troglodytes His Full L. Full Length (1-317)
RFL19212EF Recombinant Full Length Erythrocebus Patas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Erythrocebus patas (Red guenon) (Cercopithecus patas) His Full L. Full Length (1-317)
RFL19774HF Recombinant Full Length Human Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Human His Full L. Full Length (1-317aa )
RFL19973SF Recombinant Full Length Semnopithecus Entellus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Semnopithecus entellus (Hanuman langur) (Presbytis entellus) His Full L. Full Length (1-317)
RFL19982MF Recombinant Full Length Miopithecus Talapoin Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin) His Full L. Full Length (1-317)
RFL20250CF Recombinant Full Length Chaetodipus Baileyi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Chaetodipus baileyi (Bailey's pocket mouse) (Perognathus baileyi) His Full L. Full Length (1-317)
RFL20458AF Recombinant Full Length Alouatta Pigra Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Alouatta pigra (Guatemalan howler monkey) (Mexican black howler monkey) His Full L. Full Length (1-317)
RFL20641AF Recombinant Full Length Alouatta Seniculus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Alouatta seniculus (Red howler monkey) His Full L. Full Length (1-317)
RFL20828TF Recombinant Full Length Trachypithecus Cristatus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata) His Full L. Full Length (1-317)
RFL21131CF Recombinant Full Length Callimico Goeldii Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Callimico goeldii (Goeldi's marmoset) His Full L. Full Length (1-344)
RFL22448AF Recombinant Full Length Allenopithecus Nigroviridis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Allenopithecus nigroviridis (Allen's swamp monkey) His Full L. Full Length (1-317)
RFL22525MF Recombinant Full Length Mammuthus Primigenius Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Mammuthus primigenius (Siberian woolly mammoth) His Full L. Full Length (1-317)
RFL2270CF Recombinant Full Length Colobus Guereza Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey) His Full L. Full Length (1-317)
RFL23245PF Recombinant Full Length Presbytis Comata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Presbytis comata (Grizzled leaf monkey) His Full L. Full Length (1-317)
RFL23282SF Recombinant Full Length Saguinus Imperator Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Saguinus imperator (Emperor tamarin) His Full L. Full Length (1-317)
RFL23397CF Recombinant Full Length Dog Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Dog His Full L. Full Length (1-317)
RFL23573LF Recombinant Full Length Loris Tardigradus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Loris tardigradus (Slender loris) His Full L. Full Length (1-317)
RFL24495CF Recombinant Full Length Goat Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Goat His Full L. Full Length (1-317)
RFL24596RF Recombinant Full Length Rangifer Tarandus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Rangifer tarandus (Reindeer) (Cervus tarandus) His Full L. Full Length (1-317)
RFL24833SF Recombinant Full Length Saguinus Oedipus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Saguinus oedipus (Cotton-top tamarin) His Full L. Full Length (1-317)
RFL25188LF Recombinant Full Length Leontopithecus Chrysopygus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Leontopithecus chrysopygus (Golden-rumped lion tamarin) (Leontopithecus rosalia chrysopygus) His Full L. Full Length (1-318)
RFL25732DF Recombinant Full Length Dama Dama Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Dama dama (Fallow deer) (Cervus dama) His Full L. Full Length (1-317)
RFL26092VF Recombinant Full Length Varecia Variegata Rubra Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Varecia variegata rubra (Red ruffed lemur) (Varecia rubra) His Full L. Full Length (1-317)
RFL27339VF Recombinant Full Length Varecia Variegata Variegata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Varecia variegata variegata (Black and white ruffed lemur) His Full L. Full Length (1-317)
RFL28065LF Recombinant Full Length Lemur Catta Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Lemur catta (Ring-tailed lemur) His Full L. Full Length (1-317)
RFL29288AF Recombinant Full Length Alces Alces Alces Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Alces alces alces (European moose) (Elk) His Full L. Full Length (1-317)
RFL29405VF Recombinant Full Length Vulpes Lagopus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Vulpes lagopus (Arctic fox) (Alopex lagopus) His Full L. Full Length (1-317)
RFL30418CF Recombinant Full Length Cebuella Pygmaea Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Callithrix pygmaea (Pygmy marmoset) (Cebuella pygmaea) His Full L. Full Length (1-344)
RFL30884CF Recombinant Full Length Callithrix Jacchus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Callithrix jacchus (White-tufted-ear marmoset) His Full L. Full Length (1-344)
RFL30979OF Recombinant Full Length Ovibos Moschatus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Ovibos moschatus (Muskox) His Full L. Full Length (1-317)
RFL31045HF Recombinant Full Length Hylobates Lar Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Hylobates lar (Common gibbon) (White-handed gibbon) His Full L. Full Length (1-317)
RFL3134GF Recombinant Full Length Chicken Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Chicken His Full L. Full Length (1-314)
RFL3158GF Recombinant Full Length Galago Senegalensis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Galago senegalensis (Northern lesser bushbaby) (Senegal bushbaby) His Full L. Full Length (1-317)
RFL31716AF Recombinant Full Length Ateles Paniscus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Ateles paniscus (Black spider monkey) (Red-faced black spider monkey) His Full L. Full Length (1-317)
RFL31770BF Recombinant Full Length Bovine Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Bovine His Full L. Full Length (1-317)
RFL31862PF Recombinant Full Length Papio Hamadryas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Papio hamadryas (Hamadryas baboon) His Full L. Full Length (1-317)
RFL32738CF Recombinant Full Length Callithrix Argentata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Callithrix argentata (Silvery marmoset) (Mico argentatus) His Full L. Full Length (1-344)
RFL32755CF Recombinant Full Length Cebus Albifrons Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Cebus albifrons (White-fronted capuchin) His Full L. Full Length (1-316)
RFL34363NF Recombinant Full Length Nomascus Concolor Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Nomascus concolor (Black crested gibbon) (Hylobates concolor) His Full L. Full Length (1-317)
RFL34928CF Recombinant Full Length Chaetodipus Penicillatus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Chaetodipus penicillatus (Desert pocket mouse) (Perognathus penicillatus) His Full L. Full Length (1-317)
RFL36034AF Recombinant Full Length Alouatta Palliata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Alouatta palliata (Mantled howler monkey) His Full L. Full Length (1-317)
RFL36130SF Recombinant Full Length Saguinus Midas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Saguinus midas (Midas tamarin) (Golden-handed tamarin) His Full L. Full Length (1-317)
RFL36275SF Recombinant Full Length Saimiri Oerstedii Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Saimiri oerstedii (Central American squirrel monkey) His Full L. Full Length (1-317)
RFL36441CF Recombinant Full Length Chlorocebus Aethiops Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Chlorocebus Aethiops His Full L. Full Length (1-317)
RFL3748CF Recombinant Full Length Cercopithecus Diana Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Cercopithecus diana (Diana monkey) His Full L. Full Length (1-317)
RFL4535TF Recombinant Full Length Trachypithecus Obscurus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Trachypithecus obscurus (Dusky leaf-monkey) (Presbytis obscura) His Full L. Full Length (1-317)
RFL4558AF Recombinant Full Length Alouatta Sara Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Alouatta sara (Bolivian red howler monkey) His Full L. Full Length (1-317)
RFL5087MF Recombinant Full Length Macaca Silenus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Macaca silenus (Lion-tailed macaque) His Full L. Full Length (1-317)
RFL5188GF Recombinant Full Length Gorilla Gorilla Gorilla Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Gorilla gorilla gorilla (Western lowland gorilla) His Full L. Full Length (1-316)
RFL5631MF Recombinant Full Length Mouse Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-315)
RFL6739AF Recombinant Full Length Alouatta Caraya Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Alouatta caraya (Black howler monkey) His Full L. Full Length (1-317)
RFL6831PF Recombinant Full Length Papio Anubis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Papio anubis (Olive baboon) His Full L. Full Length (1-317)
RFL7457MF Recombinant Full Length Macaca Nigra Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Macaca nigra (Celebes black macaque) (Crested black macaque) His Full L. Full Length (1-317)
RFL8537HF Recombinant Full Length Hylobates Muelleri Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Hylobates muelleri (Mueller's Bornean gibbon) His Full L. Full Length (1-317)
RFL9520SF Recombinant Full Length Saguinus Geoffroyi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Saguinus geoffroyi (Geoffroy's tamarin) His Full L. Full Length (1-316)
RFL956MF Recombinant Full Length Macaca Nemestrina Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli Macaca nemestrina (Pig-tailed macaque) His Full L. Full Length (1-317)

    Involved Pathway

    MC1R involved in several pathways and played different roles in them. We selected most pathways MC1R participated on our site, such as Neuroactive ligand-receptor interaction,Melanogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Melanogenesis PRKCBB,WNT6,GSK3B,ADCY2B,FZD2,GSK3AA,PRKCBA,EDNRBA,TYRP1B,Adcy4
    Neuroactive ligand-receptor interaction GRM3,TAAR15,CHRND,APLNRA,GRID1,ADCYAP1R1A,LHB,EDNRAA,TAAR12C,P2RX7

    Protein Function

    MC1R has several biochemical functions, for example, G-protein coupled peptide receptor activity,hormone binding,melanocortin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MC1R itself. We selected most functions MC1R had, and list some proteins which have the same functions with MC1R. You can find most of the proteins on our site.

    Function Related Protein
    melanocyte-stimulating hormone receptor activity MC4R,MC3R
    ubiquitin protein ligase binding UBE2KA,LYN,TRAF6,MAP1LC3C,NKD2,ARRB2,USP13,PRKACB,MUL1,BRCA1
    G-protein coupled peptide receptor activity GPR84,GRPR,GPR37L1,RXFP3,TSHR,MCHR2,LTB4R,FSHR,NPR1,NPR3
    protein binding CBX4,NUPL1,COMTD1,SRF,PPP4R2,COL1A2,VAMP4,HIST1H3H,RTF1,CEP290
    melanocortin receptor activity MC5RB,MC4R,MC5R,MC5RA,MC2R,MC3R
    hormone binding NPR1,ADIPOR1B,MC5R,CALR,GPR30,UCN2,ADIPOR1A,NPR3,TTR,ADIPOR2

    Interacting Protein

    MC1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC1R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC1R.

    MRAP;MRAP2

    Resources

    Gene Families

    What is GPCR
    GPCRs Class A

    References

    • Duarte, CW; Stohn, JP; et al. Elevated Plasma Levels of the Pituitary Hormone Cthrc1 in Individuals with Red Hair but Not in Patients with Solid Tumors. PLOS ONE 9:-(2014).
    • Spichty, R; Balimann, M; et al. A bioassay for the detection of neutralizing antibodies against the alpha-melanocyte stimulating hormone analog afamelanotide in patients with erythropoietic protoporphyria. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 75:192-198(2013).

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