Recombinant Human MAP3K2, GST-tagged, Active

• Cat.No.: MAP3K2-351H
• Product Overview: Recombinant full-length human MEKK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 115 kDa.

Specification

• Cat. No.: MAP3K2-351H
• Description: MEKK2 (also known as mitogen-activated protein kinase (MAPK) kinase kinase 2) is a major upstream activator of the JNK/MAPK cascade. MEKK2 can mediate in vitro phosphorylation of MKK4 and MKK7 which are key MAPKs that activate JNK. In addition, MEKK2 immunoprecipitates activated JUN in an IL1-dependent manner. Rheumatoid arthritis and osteoarthritis synovial tissues show high levels of MEKK2 indicating that it may be an important activator of the JNK pathway in arthritis. Endogenous MEKK2 is localized mainly in the cytosol of unstimulated cells.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Homo sapiens ]
• Synonyms: MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK2B; MEK kinase 2; OTTHUMP00000203817; MAP/ERK kinase kinase 2; MAPK/ERK kinase kinase 2; EC 2.7.11.25; MAPKKK2; MEKK 2
• Gene ID: 10746
• mRNA Refseq: NM_006609
• Protein Refseq: NP_006600
• MIM: 609487
• UniProt ID: Q9Y2U5
• Chromosome Location: 2q14.3
• Pathway: Gap junction; GnRH signaling pathway; MAPK signaling pathway
• Function: ATP binding; MAP kinase kinase kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity