Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 2, GST-tagged

Cat. No. :

MAP3K2-1258H

Description :

MAP3K2 isa serine/threonine kinase that activates kinases involved in the MAP kinasesignaling pathway. The protein encoded by this gene is a member ofserine/threonine protein kinase family. This kinase preferentially activatesother kinases involved in the MAP kinase signaling pathway. This kinase hasbeen shown to directly phosphorylate and activate Ikappa B kinases, and thusplays a role in NF-kappa B signaling pathway. This kinase has also been foundto bind and activate protein kinase C-related kinase 2, which suggests itsinvolvement in a regulated signaling process.

Source :

Insect cells

Species :

Human

Form :

Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.

Molecular Weight :

97.2 kDa

Specific Activity :

355 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 1.39μg/ml in acoupled assay.

Concentration :

0.3 mg/ml

Storage :

Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.

OfficialSymbol :

MAP3K2

nullValue_other :

Function

ATP binding; MAPkinase kinase kinase activity; metal ion binding; protein kinase activity; nucleotidebinding; protein serine/tyreonine kinase activity

Full Length :

Full L.

Gene Name	MAP3K2 mitogen-activatedprotein kinase kinase kinase 2 [ Homo sapiens ]
Synonyms	MAP3K2; mitogen-activatedprotein kinase kinase kinase 2; MEKK2; MAPK/ERK kinase kinase 2;MEKK2B; OTTHUMP00000203817; OTTHUMP00000203818; OTTHUMP00000203819; EC2.7.11.25; MEK kinase 2; MAPKKK2; MAP/ERK kinasekinase 2
Gene ID	10746
mRNA Refseq	NM_006609
Protein Refseq	NP_006600
MIM	609487
UniProt ID	Q9Y2U5
Chromosome Location	2q14.3
Pathway	EGFR1 SignalingPathway; ErbB1 downstream signaling; Gap junction; GnRH signaling pathway; InsulinSignaling; MAPK Cascade; MAPK signaling pathway; TNF-alpha/NF-kB SignalingPathway; Trk receptor signaling mediated by the MAPK pathway

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