MAP3K2

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 2

  • Overview

    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially;activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly;phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has;also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated;signaling process.

  • Synonyms

    MAP3K2;mitogen-activated protein kinase kinase kinase 2;MEKK2;MAP/ERK kinase kinase 2;MEKK2B;M3K2_HUMAN;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2;Mitogen activated protein kinase kinase kinase 2;OTTHUMP00000203817;OTTHUMP00000203818

Recombinant Proteins

  • Human
  • Mouse
  • Insect Cell
  • Sf9 Insect Cell
  • HEK293
  • Mammalian cells
  • HEK293T
  • GST
  • Non
  • His&Fc&Avi
  • Flag
  • Myc&DDK

    Involved Pathway

    MAP3K2 involved in several pathways and played different roles in them. We selected most pathways MAP3K2 participated on our site, such as BDNF signaling pathway,EGFR1 Signaling Pathway,ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK Cascade MBP,MBPB,MAP2
    MAPK signaling pathway CACNA1B,GADD45AB,C11orf52,IL1B,RAF1A,RELB,TAB2,CACNG1,FGFR2,MAP3K6
    GnRH signaling pathway ADCY1B,MAPK9,CAMK2G,PRKCBB,MAPK1,CALM2A,CALML3,ATF4B1,MAP3K1,GNRHR1
    Gap junction SRC,GNAQ,TUBA7L,KRAS,TUBA1B,MAP2K1,TUBB1,TUBA8L2,ADCY1A,CX43
    EGFR1 Signaling Pathway AP2A1,SH3BGRL,CEACAM1,ARF4,MTA2,ABI1B,CRKL,ABI1,KRT8,KRT17
    ErbB1 downstream signaling EGR1,ARF4,CHN2,WASF2,ABI1,BAIAP2,ACTR3,NCKAP1,ACTR2,EPS8
    Insulin Signaling FLOT1,GSK3AB,STXBP3,MAP4K1,MINK1,KIF5B,MAP4K5,MYO1C,STXBP2,REG1A
    BDNF signaling pathway JAK2,DPYSL2,CSNK2A1,FRS2,BCL2L11,CSNK2A1P,EEF2,CNR1,SYN1,FRS3

    Protein Function

    MAP3K2 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K2 itself. We selected most functions MAP3K2 had, and list some proteins which have the same functions with MAP3K2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ZNF222,AFP,NCALDA,LIG1,SP8,SLC8A1,AOX3L1,MSS51,ZNF865,NRXN3B
    protein binding RPP25L,RPL14,CST5,NUFIP1,ISYNA1,C17orf62,C16orf72,DGCR6L,RAB8B,GPR143
    protein kinase activity RPS6KA3A,PKN1,TAOK1,ANKK1,STK30,CDC7,LTK,NEK5,EPHB3A,AKT1
    protein kinase binding VRK1,PTPN1,CCNYL1,SHC4,MVP,PTK2,SREBF1,USP37,SNAP91,RPS3
    ATP binding KIF14,PNCK,UBE2IB,TPK1,ATP2B1,DGKE,TAOK1,PRKAA2,IRAK4,ERCC6
    protein serine/threonine kinase activity PAK4,STK3,DYRK3,SYK,PRKCD,RPS6KA3,KALRN,GRK1B,MARK2,MAP2K3
    MAP kinase kinase kinase activity TAOK3,STK4,MAP3K13,MAP3K3,ALPK2,MAP3K15,RAF1,MAP3K6,YSK4,TAOK2

    Interacting Protein

    MAP3K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K2.

    YWHAB;YWHAE;SFN;YWHAG;STUB1;saicar

    MAP3K2 Related Signal Pathway

    Resources

    Research Area

    MAP3K
    Post-translational Modification of NFkB/IkB

    References

    • Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    • Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).

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