Recombinant Human LTA4H Protein, His-tagged

• Cat.No.: LTA4H-074H
• Product Overview: Active recombinant human LTA4H protein (1-610) with a C-terminal His tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~69 kDa
• Protein length: 1-610
• Purity: ≥90% as determined by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 mmol per min of 4-nitro-anilide (pNA) at 26 centigrade in a reaction containing 40 mM L-Ala-pNA in 50 mM Tris pH 8.0, measured by absorbance at 405 nm.
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 100 mM Tris, pH 8.0, with 100 mM potassium chloride and 20% glycerol

Gene Information

• Gene Name: LTA4H leukotriene A4 hydrolase [ Homo sapiens (human) ]
• Official Symbol: LTA4H
• Synonyms: LTA4H; leukotriene A4 hydrolase; leukotriene A-4 hydrolase; LTA-4 hydrolase; testicular secretory protein Li 27; tripeptide aminopeptidase LTA4H; EC 3.3.2.6; EC 3.4.11.4
• Gene ID: 4048
• mRNA Refseq: NM_000895
• Protein Refseq: NP_000886
• MIM: 151570
• UniProt ID: P09960