Recombinant Human LATS2

Cat.No. : LATS2-28502TH
Product Overview : Recombinant fragment, corresponding to amino acids 480-1088 of Human LATS2, expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 98kDa.
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Species : Human
Tag : Non
Protein Length : 480-1088 a.a.
Description : This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
Tissue specificity : Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 1 UBA domain.
Gene Name LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) [ Homo sapiens ]
Official Symbol LATS2
Synonyms LATS2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 2; serine/threonine-protein kinase LATS2;
Gene ID 26524
mRNA Refseq NM_014572
Protein Refseq NP_055387
MIM 604861
Uniprot ID Q9NRM7
Chromosome Location 13q11-q12
Pathway Coregulation of Androgen receptor activity, organism-specific biosystem;
Function ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity;

Not For Human Consumption!

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