Recombinant Human LATS2
Cat.No. : | LATS2-28502TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 480-1088 of Human LATS2, expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 98kDa. |
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Species : | Human |
Tag : | Non |
Protein Length : | 480-1088 a.a. |
Description : | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. |
Tissue specificity : | Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 1 UBA domain. |
Gene Name | LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) [ Homo sapiens ] |
Official Symbol | LATS2 |
Synonyms | LATS2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 2; serine/threonine-protein kinase LATS2; |
Gene ID | 26524 |
mRNA Refseq | NM_014572 |
Protein Refseq | NP_055387 |
MIM | 604861 |
Uniprot ID | Q9NRM7 |
Chromosome Location | 13q11-q12 |
Pathway | Coregulation of Androgen receptor activity, organism-specific biosystem; |
Function | ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; |
◆ Recombinant Proteins | ||
LATS2-6686Z | Recombinant Zebrafish LATS2 | +Inquiry |
LATS2-28502TH | Recombinant Human LATS2 | +Inquiry |
LATS2-301645H | Recombinant Human LATS2 protein, GST-tagged | +Inquiry |
LATS2-6821Z | Recombinant Zebrafish LATS2 | +Inquiry |
LATS2-1541H | Recombinant Human LATS2, Unactive, GST-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
LATS2-4813HCL | Recombinant Human LATS2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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