LATS2
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Official Full Name
large tumor suppressor kinase 2 -
Overview
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] -
Synonyms
LATS2;large tumor suppressor kinase 2;KPM;serine/threonine-protein kinase LATS2;warts-like kinase;serine/threonine kinase KPM;large tumor suppressor homolog 2;serine/threonine-protein kinase kpm;LATS, large tumor suppressor, homolog 2;kinase phosphorylated during mitosis protein;LATS (large tumor suppressor, Drosophila) homolog 2
Recombinant Proteins
- Human
- Zebrafish
- Sf9 Cells
- Mammalian Cells
- HEK293
- E.coli
- GST
- Non
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LATS2-1541H | Recombinant Human LATS2, Unactive, GST-tagged | Sf9 Cells | Human | GST | 480-1088 aa |
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| LATS2-28502TH | Recombinant Human LATS2 | Human | Non | 480-1088 a.a. |
|
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| LATS2-381H | Recombinant Human LATS2, GST-tagged | Sf9 Cells | Human | GST | 480-1088 a.a. |
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| LATS2-6686Z | Recombinant Zebrafish LATS2 | Mammalian Cells | Zebrafish | His |
|
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| LATS2-6821Z | Recombinant Zebrafish LATS2 | Mammalian Cells | Zebrafish | His |
|
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| LATS2-4813HCL | Recombinant Human LATS2 293 Cell Lysate | HEK293 | Human | Non |
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| LATS2-301645H | Recombinant Human LATS2 protein, GST-tagged | E.coli | Human | GST | Met140-Pro424 |
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Involved Pathway
LATS2 involved in several pathways and played different roles in them. We selected most pathways LATS2 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | SCRIB,BMP4,YWHAE,TGFB2,PPP1CC,PRKCI,YWHAZ,PPP2R1B,WNT3,CRB2 |
Protein Function
LATS2 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS2 itself. We selected most functions LATS2 had, and list some proteins which have the same functions with LATS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TECPR1,TNFRSF14,LILRB3,GSTP1,CD300LH,CHD2,EPHA10,MAFB,RAB3A,RASA1 |
| metal ion binding | CAPN8,PPM1E,LMX1BB,OVCH2,FGD3,AMPD3,ZNF362B,ZNF277,DTX1,CYP4F18 |
| ATP binding | MAPK14A,UBE2E1,HSP70L,MYO7B,YME1L1B,RTEL1,LIMK1,DDX50,MAP4K2,TOP2A |
| protein serine/threonine kinase activity | MAP3K10,LRRK1,PKN2,NLK2,MELK,PIK3R4,MAP4K6,PLK4,ERN2,UHMK1 |
Interacting Protein
LATS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS2.
MOB1A;MOB1B;AJUBA;VPRBP;SNAI1;UBI1;LATS1;LMNA
Resources
Related Services
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References
- Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).
- Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).
