Recombinant Human KL Protein (Glu34-Ser981), N-His tagged

• Cat.No.: KL-3302H
• Product Overview: Recombinant human KL (Glu34-Ser981) protein fused with the N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 111.35 kDa
• Protein length: Glu34-Ser981
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: KL klotho [ Homo sapiens (human) ]
• Official Symbol: KL
• Synonyms: KL; klotho
• Gene ID: 9365
• mRNA Refseq: NM_004795
• Protein Refseq: NP_004786
• MIM: 604824
• UniProt ID: Q9UEF7

Reviews

01/31/2021

The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

01/22/2019

Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

07/22/2016

Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

Q&As

How does KL protein affect cognitive function?

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use?

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process?

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings?

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies?

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.