Recombinant Human Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4

• Cat.No.: KIR2DS4-147H
• Product Overview: Recombinant KIR2DS4 protein produced in E.Coli is a single, non-glycosylated polypeptide chain and was purified by FPLC gel-filtration chromatography (202 aa, 22.2 kDa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: An activating Killer Cell Ig-like Receptor(KIR, previously called p50 KIR, p50.3, cl39, or KAR-K1), which may recognize class I MHC molecules. The protein coding region of the extracellular domain of KIR2DS4(amino acids 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DS4 was overexpressed as insoluble protein aggregates(inclusion bodies). The recombinant KIR2DS4 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5).
• Molecular Weight: 22.2 kDa (202 aa).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Amino acid Sequence: MEGVHRKPSF LALPGHLVKS EETVILQCWS DVMFEHFLLH REGKFNNTLH LIGEHHDGVS KANFSIGPMM PVLAGTYRCY GSVPHSPYQL SAPSDPLDMV IIGLYEKPSL SAQPGPTVQA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAVRSINGTF QADFPLGPAT HGGTYRCFGS FRDAPYEWSN SSDPLLVSVT GN
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 [ Homo sapiens ]
• Synonyms: KIR2DS4; KIR1D; KIR412; KKA3; MGC120019; MGC125315; MGC125317; NKAT-8; NKAT8; PAX; cl-39; Killer cell immunoglobulin-like receptor; nkat8; CD158I; CD158i; CL-17; CD158 antigen-like family member I; CD158i antigen; KIR antigen 2DS4; MHC class I NK cell receptor; Natural killer-associated transcript 8; P58 natural killer cell receptor clone CL-39; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; killer inhibitory receptor 4-1-2; natural killer cell inhibitory receptor; p58 NK receptor.
• Gene ID: 3809
• mRNA Refseq: NM_012314
• Protein Refseq: NP_036446
• MIM: 604955
• UniProt ID: P43632
• Chromosome Location: 19q13.4
• Pathway: Antigen processing and presentation.
• Function: receptor activity.