KIR2DS4
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Official Full Name
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 -
Overview
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. -
Synonyms
KIR2DS4;killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4;killer cell immunoglobulin-like receptor 2DS4;CD158i;cl 39;KKA3;nkat8;CD158 antigen like family member I;CD158i antigen;CL 17;CL17;CL39;Killer cell immunoglobulin like receptortwo domains short cytoplasmic tail 4;Killer inhibitory receptor 4 1 2;KIR antigen 2DS4;KIR1D;KIR412;MGC120019;MGC125315;MGC125317;MHC class I NK cell receptor;Natural killer associated transcript 8;Natural killer cell inhibitory receptor;NKAT 8;P58 natural killer cell receptor clone CL 39;p58 NK receptor;NKAT-8;OTTHUMP00000199030;p58 NK receptor CL-39/CL-17;killer inhibitory receptor 4-1-2;CD158 antigen-like family member I;natural killer-associated transcript 8;na
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIR2DS4-147H | Recombinant Human Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 | E.coli | Human | Non |
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| KIR2DS4-28650TH | Recombinant Human KIR2DS4 | E.coli | Human | Non | 1-202 a.a. |
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| KIR2DS4-1340H | Recombinant Human KIR2DS4 Protein (Gln22-Ser302), N-His tagged | E.coli | Human | His | Gln22-Ser302 |
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| KIR2DS4-4342H | Recombinant Human KIR2DS4 Protein (Met1-His245), C-His tagged | Mammalian Cells | Human | His | Met1-His245 |
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| RFL5573HF | Recombinant Full Length Human Killer Cell Immunoglobulin-Like Receptor 2Ds4(Kir2Ds4) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (22-304) |
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Involved Pathway
KIR2DS4 involved in several pathways and played different roles in them. We selected most pathways KIR2DS4 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HSP90AB1,CTSL1,HLA-E,HLA-DRB5,CTSS,KLRC3,HSPA6,KIR2DS2,PSME2,HLA-DQA1 |
| Natural killer cell mediated cytotoxicity | Casp3,Raet1a,NCR2,RAC2,Fasl,VAV2,SOS1,FCER1G,IFNA16,SYK |
Protein Function
KIR2DS4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DS4 itself. We selected most functions KIR2DS4 had, and list some proteins which have the same functions with KIR2DS4. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
KIR2DS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DS4.
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