Recombinant Human KAT8 , GST-tagged

• Cat.No.: KAT8-6957H
• Product Overview: Recombinant human KAT8 (2-467; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 2-467 aa
• Description: KAT8 (MYST1) or MYST histone acetyltransferase 1 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein which play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. MYST1 have a chromodomain that involved in protein-protein interactions and targeting transcriptional regulators to chromatin.MYST histone acetyltransferase 1 is also involved in ATM function.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~83 kDa
• Purity: >80%
• Applications: Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1 μg/μ

Gene Information

• Gene Name: KAT8 K(lysine) acetyltransferase 8 [ Homo sapiens ]
• Official Symbol: KAT8
• Synonyms: KAT8; K(lysine) acetyltransferase 8; MYST histone acetyltransferase 1 , MYST1; histone acetyltransferase KAT8; FLJ14040; hMOF; MOF; MYST-1; lysine acetyltransferase 8; histone acetyltransferase MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; probable histone acetyltransferase MYST1; ortholog of Drosophila males absent on the first (MOF); MYST1
• Gene ID: 84148
• mRNA Refseq: NM_032188
• Protein Refseq: NP_115564
• MIM: 609912
• UniProt ID: Q9H7Z6
• Chromosome Location: 16p11.1
• Pathway: p53 pathway, organism-specific biosystem
• Function: acetyltransferase activity; histone acetyltransferase activity; contributes_to histone acetyltransferase activity (H4-K16 specific); contributes_to histone acetyltransferase activity (H4-K5 specific); contributes_to histone acetyltransferase activity (H4-K8 specific); metal ion binding; methylated histone residue binding; protein binding; transcription factor binding