Recombinant Human K(Lysine) Acetyltransferase 8, GST-tagged

• Cat.No.: KAT8-1602H
• Product Overview: Recombinant human KAT8 (2-467; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: KAT8-1602H
• Description: KAT8 (MYST1) or MYST histone acetyltransferase 1 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein which play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. MYST1 have a chromodomain that involved in protein-protein interactions and targeting transcriptional regulators to chromatin. MYST histone acetyltransferase 1 is also involved in ATM function.
• Applications: Western Blot
• Molecular Weight: 83 kDa
• Expression System: Sf9 insect cells using baculovirus.
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: > 80 %
• Concentration: 0.1 ug/ul
• Sequences: 2-467
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: p53 pathway
• Protein length: 2-467 a.a.

Gene Information

• Gene Name: KAT8 K(lysine) acetyltransferase 8 [ Homo sapiens ]
• Official Symbol: KAT8
• Synonyms: KAT8; MOF; hMOF; MYST1; FLJ14040; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; EC 2.3.1.48; histone acetyltransferase MYST1; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1
• Gene ID: 84148
• mRNA Refseq: NM_032188
• Protein Refseq: NP_115564
• MIM: 609912
• UniProt ID: Q9H7Z6
• Chromosome Location: 16p11.2
• Function: acetyltransferase activity; histone acetyltransferase activity; metal ion binding; methylated histone residue binding; protein binding; transcription factor binding