Recombinant Human ITPR1 Protein, His-tagged

• Cat.No.: ITPR1-2346H
• Product Overview: Recombinant Human ITPR1 Protein (Gly112-Val287) with a N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Gly112-Val287
• Description: This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 23.5 kDa
  Accurate Molecular Mass: 27 kDa
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 [ Homo sapiens (human) ]
• Official Symbol: ITPR1
• Synonyms: ITPR1; inositol 1,4,5-trisphosphate receptor, type 1; SCA15, SCA16, spinocerebellar ataxia 15, spinocerebellar ataxia 16; inositol 1,4,5-trisphosphate receptor type 1; Insp3r1; IP3R1; IP3R 1; IP3 receptor; type 1 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 1; type 1 inositol 1,4,5-trisphosphate receptor; IP3R; SCA15; SCA16; INSP3R1; DKFZp313E1334; DKFZp313N1434
• Gene ID: 3708
• mRNA Refseq: NM_001099952
• Protein Refseq: NP_001093422
• MIM: 147265
• UniProt ID: Q14643