ITPR1
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Official Full Name
Itpr1 inositol 1,4,5-trisphosphate receptor 1 -
Synonyms
ITPR1;inositol 1,4,5-trisphosphate receptor 1;inositol 1,4,5-trisphosphate receptor type 1;IP3R 1;insP3R1;IP3 receptor;opisthotonus;InsP3R type I;protein PCD-6;InsP>3<R type I;type 1 InsP3 receptor;Purkinje cell protein 1;inositol 1,4,5-triphosphate receptor 1;type 1 inositol 1,4,5-trisphosphate receptor;inositol 1,4,5-trisphosphate-binding protein P400;opt;Ip3r;P400;Pcp1;IP3R1;Pcp-1;D6Pas2;InsP3R;Itpr-1;Gm10429;ENSMUSG00000072853
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITPR1-4075C | Recombinant Chicken ITPR1 | Mammalian Cells | Chicken | His |
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| ITPR1-8389M | Recombinant Mouse ITPR1 Protein | Mammalian Cells | Mouse | His |
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| ITPR1-2346H | Recombinant Human ITPR1 Protein, His-tagged | E.coli | Human | His | Gly112-Val287 |
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| ITPR1-4655M | Recombinant Mouse ITPR1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ITPR1-4655M-B | Recombinant Mouse ITPR1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ITPR1-4945H | Recombinant Human ITPR1 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | PRKCBB,KCNMA1A,KCNMB2,MAP2K1,PRKCDA,CALM3B,PLCB3,MAP2K2A,ROCK2A,CACNA1C |
| Alzheimers disease | COX7A2L,NDUFC1,NDUFA11,PPP3CB,NDUFAB1,IL1B2,NDUFS1,NDUFC2-KCTD14,TNFRSF1A,MAPK1 |
| Proteoglycans in cancer | FZD2,RDX,ELK1,ERBB2,MAPK11,PRKACB,ROCK1,FZD10,GAB1,ITGB5 |
| Pancreatic secretion | FXYD2,CLCA5,Slc4a2,PRSS3,RAC1,CPA3,RAB8A,PLA2G1B,PRKCG,CCKAR |
| cGMP-PKG signaling pathway | FXYD2,PIK3CA,KCNMB4,PLCB2,BNP,VDAC3,SRF,MYH7,PIK3R5,PPP1CC |
| Long-term potentiation | GRIA1,GRIA2,PPP3CA,PPP3R1,GRIN2C,MAPK3,PLCB4,MAP2K2,GRIN2D,PPP1CA |
| Aldosterone synthesis and secretion | HSD3B5,DAGLB,ATF2,KCNK3,PLCB4,ADCY8,PRKCE,NR4A1,ORAI1,CACNA1G |
| Platelet activation | ITPR3,ARHGEF12,SYK,ACTB,ORAI1,MYLK3,PLCB4,ARHGEF1,LCP2,VASP |
| Phosphatidylinositol signaling system | INPP5B,PIK3CB,PIP5K1AA,CALML5,CDS1,MTMR1A,PIK3R3,INPPL1A,PRKCBA,ITPKB |
Protein Function
ITPR1 has several biochemical functions, for example, calcium channel activity,calcium channel inhibitor activity,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel activity | TRPM6,AKR1C1,CACNA1C,TRPV1,RYR2,TRPC6A,CACNG8A,SLC24A2,UBXN6,CACNG2B |
| protein phosphatase binding | PIK3R2,PPME1,KAT2A,EIF2AK3,MAP3K5,Itga10&Itgb1,PPARG,TRP53,VRK3,CDH2 |
| protein binding | GYG1,C19orf60,NRP1,CEP152,SOCS4,FANCF,KRT1,ACSS1,ERCC6,PCSK5 |
| phosphatidylinositol binding | P2RX2,SNX10B,SNX12,NOXO1A,GRB7,SNX27A,SNX13,HIP1,TULP4,NISCH |
| ion channel activity | KCNC1A,KCNC3B,TRPM1A,KCNG4A,RYR1B,TRPM4A,TRPC2B,SCN1LAB,TRPC2,KCNC3A |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | AKR1C1,ITPR2,ITPR3 |
| protein C-terminus binding | BAIAP2,ERBB2,DGKZ,PXK,VPS4A,XRCC6,FBLN1,VIM,VGLL2,CDK7 |
| calcium channel inhibitor activity | SLC30A1,SLC30A1A,FKBP1B,STX1A,TNNI3,FKBP1AB,FKBP1AA,AMBP,PHPT1,CCDC109B |
| protein complex binding | LCA5,PAFAH1B1,TULP3,TUB,PLK2,CALCA,SIX2,NSF,STK11,NR0B2 |
Interacting Protein
ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.
Erp44;Hspa9;Htt;Vdac1;Aco2;Ppif;Hap1;Hap1;PRKACB;HTT;CALM1;Ywhae;Ywhaz
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References
- Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
- Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).
