Recombinant Human ITGAL Protein, DYKDDDDK-tagged

• Cat.No.: ITGAL-151H
• Product Overview: Recombinant protein from the full-length sequence of Homo sapiens integrin subunit alpha L (ITGAL), transcript variant 1 (NM_002209), with a DYKDDDDK tag was expressed in human cell.

Specification

• Species: Human
• Source: Human Cells
• Tag: Flag
• Description: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 128.7 kDa
• Endotoxin: < 0.1 ng/μg of protein (< 1 EU /μg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Gene Information

• Gene Name: ITGAL integrin subunit alpha L [ Homo sapiens (human) ]
• Official Symbol: ITGAL
• Synonyms: ITGAL; integrin subunit alpha L; CD11A; LFA-1; LFA1A; integrin alpha-L; CD11 antigen-like family member A; LFA-1 alpha; LFA-1A; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; lymphocyte function-associated antigen 1, alpha polypeptide
• Gene ID: 3683
• mRNA Refseq: NM_002209
• Protein Refseq: NP_002200
• MIM: 153370
• UniProt ID: P20701