Itgal

  • Official Full Name

    integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1

  • Overview

    ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • Synonyms

    ITGAL;integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1;alpha polypeptide);CD11A;LFA-1;LFA1A;integrin alpha-L;LFA-1A;LFA-1 alpha;integrin gene promoter;CD11 antigen-like family member A;lymphocyte function-associated antigen 1;leukocyte adhesion glycoprotein LFA-1 alpha chain;leukocyte function-associated molecule 1 alpha chain;antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • HEK293
  • Yeast
  • Human Cells
  • Mammalian Cells
  • His&T7
  • Non
  • His
  • His&Fc&Avi
  • Flag
  • Myc&DDK

    Involved Pathway

    Itgal involved in several pathways and played different roles in them. We selected most pathways Itgal participated on our site, such as Rap signaling pathway,Cell adhesion molecules (CAMs),Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with Itgal were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway ITGAM,FGF8,RAC1,PIK3CD,PRKCB,FGF13,CALML3,CALM1,RASSF5,FGF12
    Natural killer cell mediated cytotoxicity TNFRSF10D,KLRK1,PRKCA,ULBP1,PAK1,KLRC3,IFNB1,KLRC2,PPP3R2,TYROBP
    Malaria IL1B,TLR2,THBS2,HBA1,ITGB2,GYPA,HBA-A2,CD81,KLRC4-KLRK1,Ccl12
    Cell adhesion molecules (CAMs) NLGN2A,MHC1UEA,CLDN20,NRXN2,HLA-DRA,CDH5,CLDN7,CDH4,CLDN5A,CTLA4
    Staphylococcus aureus infection C5,FPR3,Itgam&Itgb2,HLA-DRB3,HLA-DPA1,MASP1,C2,HLA-DQA2,C5AR1,cgr2b
    Regulation of Actin Cytoskeleton SCINLB,FGFR2,ABI2,ITGAV,FGF12A,FGF11A,ARHGEF4,PDGFAB,ACTN3,RAF1
    Leukocyte transendothelial migration CDH5,RASSF5,PIK3CA,CLDN20,VCAM1,PIK3CD,PLCG1,CLDN11,F11R,RAC1
    Rheumatoid arthritis HLA-DRB1,ATP6V1C1,ATP6V1F,ATP6V0E1,ICAM1,ATP6V0B,ATP6V1B1,IL23,TNF,TEK
    Viral myocarditis HLA-DRB4,CAV1,FYN,HLA-DRB3,CASP9,CYCS,ACTB,EIF4G3,CD80,HLA-DPA1

    Protein Function

    Itgal has several biochemical functions, for example, ICAM-3 receptor activity,cell adhesion molecule binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Itgal itself. We selected most functions Itgal had, and list some proteins which have the same functions with Itgal. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding LMAN2,LNX2B,LRP2,RXRBB,ZBTB33,PAPD4,SH3RF3,PSMD14,PEG3,YME1L1
    cell adhesion molecule binding ITGA4,EZR,PKP3,CADM1A,PVRL2,NCR3,CADM3,ITGB2,ITGB1,CADM2
    ICAM-3 receptor activity ITGB2,CLEC4M
    protein binding KLHL3,PRKCB,PPP1R12C,FGFR1OP,MRPL28,FGFR1OP2,RTP3,BCL2L15,CCDC67,TMEM147

    Interacting Protein

    Itgal has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Itgal here. Most of them are supplied by our site. Hope this information will be useful for your research of Itgal.

    PTPRC;q9wmx2-pro_0000037551;env;ICAM1;ICAM3;VHL;Rassf5;RANBP9;MYC

    Resources

    References

    • Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
    • Williams, AS; Kang, L; et al. Integrin alpha 1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6546-6557(2015).

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