Recombinant Human Integrin-Linked Kinase, His-tagged

• Cat.No.: ILK-904H
• Product Overview: ILK1 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 452 amino acids fragment ( 1-452 ) having a molecular mass of 55.92 kDa and fused with a 4.5 kDa amino-terminal hexahistidine tag.

Specification

• Cat. No.: ILK-904H
• Description: ILK1 ( Integrin-linked kinase ) is a serine/threonine protein kinase, containing 4 ankyrin-like repeats. ILK1 regulates a number of biological properties which include: anchorage-independent cell cycle progression, tumor cell invasion and apoptosis. ILK1 can also be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells.
• Source: Human
• Host: Escherichia Coli.
• Form: ILK1 protein is supplied in 25 mM Sodium Acetate (pH 4.8) and 50 % glycerol.
• Purity: Greater than 95.0 % as determined by SDS-PAGE.
• Physical Appearance: Sterile Filtered clear solution
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
• Protein length: 1-452 a.a.

Gene Information

• Gene Name: ILK integrin-linked kinase [ Homo sapiens ]
• Official Symbol: ILK
• Synonyms: ILK; integrin-linked kinase; P59; ILK-2; DKFZp686F1765; integrin-linked protein kinase; ILK-1; p59ILK; OTTHUMP00000164591; OTTHUMP00000229991; OTTHUMP00000229995; OTTHUMP00000229996; integrin-linked kinase-2; 59 kDa serine/threonine-protein kinase
• Gene ID: 3611
• mRNA Refseq: NM_001014794
• Protein Refseq: NP_001014794
• MIM: 602366
• UniProt ID: Q13418
• Chromosome Location: 11p15.4
• Pathway: Bacterial invasion of epithelial cells; Cell junction organization; Cell-extracellular matrix interactions; Endometrial cancer; Eukaryotic Transcription Initiation; Focal adhesion; Focal Adhesion; Integrin-mediated cell adhesion; Integrins in angiogenesis; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Osteopontin-mediated events; PPAR signaling pathway
• Function: ATP binding; SH3 domain binding; integrin binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; signal transducer activity