ILK
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Official Full Name
integrin-linked kinase -
Overview
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
ILK;integrin-linked kinase;integrin-linked protein kinase;ILK-1;p59ILK;integrin-linked kinase-2;59 kDa serine/threonine-protein kinase;P59;ILK-2;DKFZp686F1765
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Human
- HEK293T
- Mamanlian cells
- Wheat Germ
- In Vitro Cell Free System
- Insect cells
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
- GST
Involved Pathway
ILK involved in several pathways and played different roles in them. We selected most pathways ILK participated on our site, such as PPAR signaling pathway,Focal adhesion,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ILK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | THBS4A,DIAP1,RAP1B,MYL12.1,PDGFA,GRB2A,RAP1AB,ACTB,IGF1,CAV2 |
| Endometrial cancer | TRP53,CCND1,AKT2,MAP2K2,MAP2K1,LEF1,TCF7L2,BRAF,RAF1,PIK3CD |
| PPAR signaling pathway | MMP1A,RXRBA,MMP1,ACSL1B,FABP7A,RXRA,SCP2A,RXRAA,PPARD,FABP4 |
| Bacterial invasion of epithelial cells | CTNNA1,SHC4,HCLS1,SEPT9,SHC3,SRC,CAV2,WASF2,SEPT2,MAD2L2 |
Protein Function
ILK has several biochemical functions, for example, ATP binding,SH3 domain binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILK itself. We selected most functions ILK had, and list some proteins which have the same functions with ILK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | ADAM12,CYBA,GJA1,UVRAG,MAPK15,EFS,CD3E,ARHGAP17,NCKIPSD,KHDRBS2 |
| protein kinase binding | CD4,FBXO5,KCNH1,MAPT,KCNQ3,CDK5RAP2,TENC1,SKI,NSF,DLG1L |
| integrin binding | CD226,COL16A1,ADAM15,WISP1A,ACTN3,CTGFB,EGFL6,P4HB,ACTN1,SEMA7A |
| protein serine/threonine kinase activity | DYRK1B,TAF1L,TSSK3,NLK1,BMPR1AA,CAMKK1A,CAMK1GA,PRKG1A,TTBK1,PASK |
| signal transducer activity | CXCR2,DRD2A,GNG13,PTGER1C,GNG12,OLFR469,SUFU,PTGER2A,VAPA,YARS |
| ATP binding | VPRBP,MAP3K13,SNRK,DARS2,CDC42BPG,CKMT2B,CHEK2,HIPK3B,LCK,STK30 |
| protein binding | FARSA,TAF13,EFHA1,CRABP1,IL1RAPL1,BCL7A,MS4A12,CDK9,ANKRA2,FANCA |
Interacting Protein
ILK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILK here. Most of them are supplied by our site. Hope this information will be useful for your research of ILK.
PARVA;LIMS1
Resources
Research Area
Kinases and Phosphatases in Endothelial CellsIntracellular Kinases in the Akt Pathway
Adherens Junction Proteins in VSMC
EMT Induction
Invadopodia Molecules
Kinases Localized to Focal Adhesions
Related Services
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References
- Li, T; Zhu, Y; et al. RHO KINASE ACTS AS A DOWNSTREAM MOLECULE TO PARTICIPATE IN PROTEIN KINASE C epsilon REGULATION OF VASCULAR REACTIVITY AFTER HEMORRHAGIC SHOCK IN RATS. SHOCK 42:239-245(2014).
- Locatelli, M; Buelli, S; et al. Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1786-1798(2014).
