Recombinant Human ILK, MYC/DDK-tagged

• Cat.No.: ILK-12H
• Product Overview: Recombinant Human ILK, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants.
• Source: HEK293 cells
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 51.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: ILK integrin-linked kinase [ Homo sapiens (human) ]
• Official Symbol: ILK
• Synonyms: ILK-1; ILK-2; 59 kDa serine/threonine-protein kinase; p59; p59ILK; ILK; integrin-linked kinase; P59; DKFZp686F1765; ILK; integrin-linked kinase; EC 2.7.11.1; ILK2
• Gene ID: 3611
• mRNA Refseq: NM_001014794
• Protein Refseq: NP_001014794
• MIM: 602366
• UniProt ID: Q13418
• Chromosome Location: 11p15.4
• Pathway: Bacterial invasion of epithelial cells; Cell junction organization; Cell-extracellular matrix interactions
• Function: ATP binding; SH3 domain binding; integrin binding