Recombinant Human IMPA1 Protein, His-tagged
Cat.No. : | IMPA1-720H |
Product Overview : | Recombinant Human IMPA1(Met1-Asp277), transcript variant 2, fused with His tag at C-terminal was expressed in E. coli. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 1-277 a.a. |
Description : | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Form : | 20mM Phosphate buffer, 150mM NaCl, pH 7.25. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Molecular Mass : | 32.3 kDa |
Endotoxin : | < 0.1 EU per µg protein as determined by LAL test |
Purity : | >95% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name | IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 [ Homo sapiens ] |
Official Symbol | IMPA1 |
Synonyms | IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1; IMP; |
Gene ID | 3612 |
mRNA Refseq | NM_001144878 |
Protein Refseq | NP_001138350 |
MIM | 602064 |
UniProt ID | P29218 |
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IMPA1-2712H | Recombinant Human IMPA1 protein(11-270 aa), C-His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
IMPA1-5214HCL | Recombinant Human IMPA1 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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