IMPA1
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Official Full Name
inositol(myo)-1(or 4)-monophosphatase 1 -
Overview
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009] -
Synonyms
IMPA1;inositol(myo)-1(or 4)-monophosphatase 1;IMP;IMPA;inositol monophosphatase 1;IMP 1;IMPase 1;inositol-1(or 4)-monophosphatase 1;lithium-sensitive myo-inositol monophosphatase A1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- DDK
- Myc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IMPA1-2824H | Recombinant Human IMPA1, His-tagged | E.coli | Human | His |
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| IMPA1-29490TH | Recombinant Human IMPA1, His-tagged | E.coli | Human | His | 277 amino acids |
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| IMPA1-3056R | Recombinant Rat IMPA1 Protein | Mammalian Cells | Rat | His |
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| IMPA1-318H | Recombinant Human IMPA1 protein, His-tagged | E.coli | Human | His | Met1-Asp277 |
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| IMPA1-720H | Recombinant Human IMPA1 Protein, His-tagged | E.coli | Human | His | 1-277 a.a. |
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| IMPA1-841Z | Recombinant Zebrafish IMPA1 | Mammalian Cells | Zebrafish | His |
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| IMPA1-5214HCL | Recombinant Human IMPA1 293 Cell Lysate | HEK293 | Human | Non |
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| IMPA1-2712H | Recombinant Human IMPA1 protein(11-270 aa), C-His-tagged | E.coli | Human | His | 11-270 aa |
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| IMPA1-2712R | Recombinant Rat IMPA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| IMPA1-2712R-B | Recombinant Rat IMPA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Impa1-3529M | Recombinant Mouse Impa1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| IMPA1-5144H | Recombinant Human IMPA1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| IMPA1-5557H | Recombinant Human IMPA1 protein, His-tagged | E.coli | Human | His | 292aa(including fusion tag) |
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| IMPA1-5858HF | Recombinant Full Length Human IMPA1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 277 amino acids |
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| IMPA1-770H | Recombinant Human IMPA1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
IMPA1 involved in several pathways and played different roles in them. We selected most pathways IMPA1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | DGKAA,INPP1,CALM3,ITPR1,SYNJ2,MTM1,PIP5K1AA,IMPA2,INPP5A,PLCD1 |
| Metabolic pathways | CMASA,PLA2G4C,PDHA1A,MGAT2,UGT1AB,Cel,CERS2A,GULO,CYP1A,MBOAT2B |
| Inositol phosphate metabolism | IP6K3,NUDT4,PIP5K1AA,MTMR7,INPP5A,MTMR1B,INPP4A,PLCZ1,PIK3C2A,SYNJ2 |
Protein Function
IMPA1 has several biochemical functions, for example, identical protein binding,inositol monophosphate 1-phosphatase activity,inositol monophosphate 3-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA1 itself. We selected most functions IMPA1 had, and list some proteins which have the same functions with IMPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol monophosphate 3-phosphatase activity | IMPAD1,IMPA2 |
| lithium ion binding | PDXK |
| protein homodimerization activity | IKBKB,CER1,IMPA2,TCF3A,ABCD1,MYPOP,IRAK3,TGFB2,PLCB1,RXRB |
| inositol monophosphate 4-phosphatase activity | IMPAD1,IMPA2 |
| magnesium ion binding | GEM,IDH1,EPHX2,RPS6KA3,WEE2,ITPK1,RPS6KA5,FDXACB1,RPS6KAL,DXO |
| manganese ion binding | PPM1NB,XPNPEP1,B4GALT7,SOD2,PCK1,PPM1AA,DYRK2,MRE11A,GALNT2,PPEF1 |
| inositol monophosphate 1-phosphatase activity | IMPA2,IMPAD1 |
| identical protein binding | FHIT,STXBP1,SHARPIN,CDC42,ALAD,NEFL,UGP2,UBE4A,SETX,SH3GLB1 |
| protein binding | DYNC2LI1,NEK3,IL6R,RPLP1,SAP30BP,RBM14,NEDD8,REEP5,OTUB2,PFN1 |
Interacting Protein
IMPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA1.
IMPA2;Impa1;E2F3
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References
- Sacchi, R; Gardell, AM; et al. Osmotic Regulation and Tissue Localization of the Myo-Inositol Biosynthesis Pathway in Tilapia (Oreochromis mossambicus) Larvae. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL GENETICS AND PHYSIOLOGY 321:457-466(2014).
- Sade, Y; Kara, NZ; et al. Beware of your mouse strain; differential effects of lithium on behavioral and neurochemical phenotypes in Harlan ICR mice bred in Israel or the USA. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124:36-39(2014).
