IMPA1

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    inositol(myo)-1(or 4)-monophosphatase 1
  • Overview

    This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
  • Synonyms

    IMPA1;inositol(myo)-1(or 4)-monophosphatase 1;IMP;IMPA;inositol monophosphatase 1;IMP 1;IMPase 1;inositol-1(or 4)-monophosphatase 1;lithium-sensitive myo-inositol monophosphatase A1

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
IMPA1-2824H Recombinant Human IMPA1, His-tagged E.coli Human His
IMPA1-29490TH Recombinant Human IMPA1, His-tagged E.coli Human His 277 amino acids
IMPA1-3056R Recombinant Rat IMPA1 Protein Mammalian Cells Rat His
IMPA1-318H Recombinant Human IMPA1 protein, His-tagged E.coli Human His Met1-Asp277
IMPA1-720H Recombinant Human IMPA1 Protein, His-tagged E.coli Human His 1-277 a.a.
IMPA1-841Z Recombinant Zebrafish IMPA1 Mammalian Cells Zebrafish His
IMPA1-5214HCL Recombinant Human IMPA1 293 Cell Lysate HEK293 Human Non
IMPA1-2712H Recombinant Human IMPA1 protein(11-270 aa), C-His-tagged E.coli Human His 11-270 aa
IMPA1-2712R Recombinant Rat IMPA1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IMPA1-2712R-B Recombinant Rat IMPA1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Impa1-3529M Recombinant Mouse Impa1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
IMPA1-5144H Recombinant Human IMPA1 Protein, GST-tagged Wheat Germ Human GST
IMPA1-5557H Recombinant Human IMPA1 protein, His-tagged E.coli Human His 292aa(including fusion tag)
IMPA1-5858HF Recombinant Full Length Human IMPA1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 277 amino acids
IMPA1-770H Recombinant Human IMPA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

Involved Pathway

IMPA1 involved in several pathways and played different roles in them. We selected most pathways IMPA1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathways ABP1,SGMS1,MGAT2,PLCB4,COX7C,HMGCLL1,GUK1,ATP6V1F,GUSB,MAT2AB
Phosphatidylinositol signaling system PLCG2,SYNJ2,PIK3R3B,PLCZ1,IPMKB,INPP5J,PIK3CA,DGKAA,MTMR3,INPP4AB
Inositol phosphate metabolism PIK3C3,MIOX,PIP5K2,PI4K2A,INPP5E,PI4KB,PTENA,PIP5K1BB,PIK3C2A,PTENB

Protein Function

IMPA1 has several biochemical functions, for example, identical protein binding,inositol monophosphate 1-phosphatase activity,inositol monophosphate 3-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA1 itself. We selected most functions IMPA1 had, and list some proteins which have the same functions with IMPA1. You can find most of the proteins on our site.

Function Related Protein
identical protein binding CEACAM5,CBY1,COL18A1,KRTAP10-5,TPRGL,TRIM23,MCM6,TRIP13,GNPNAT1,BNIP2
protein homodimerization activity BHLHB9,ABCB9,GLIPR2,CADM2A,DRD2,TCF3A,KCNK3,WHRN,EFR3A,SLC11A1
manganese ion binding CDIPT,PPM1A,SLC11A2,PEPD,FEN1,XPNPEP1,PPM1NB,ABL1,MPPE1,GYLTL1B
inositol monophosphate 1-phosphatase activity IMPAD1,IMPA2
protein binding S100A8,ZC3H8,GYPB,WBP1L,NAB2,FAM212A,GNG12,GGNBP2,FREM2,CD244
inositol monophosphate 3-phosphatase activity IMPA2,IMPAD1
magnesium ion binding RPS6KA6,RPS6KAL,PPM1BB,ZAK,TOP2A,WRN,ADSSL1,THTPA,PTENA,ADPRH
inositol monophosphate 4-phosphatase activity IMPA2,IMPAD1
lithium ion binding PDXK

Interacting Protein

IMPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA1.

IMPA2;Impa1;E2F3

Resources

References

  • Sacchi, R; Gardell, AM; et al. Osmotic Regulation and Tissue Localization of the Myo-Inositol Biosynthesis Pathway in Tilapia (Oreochromis mossambicus) Larvae. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL GENETICS AND PHYSIOLOGY 321:457-466(2014).
  • Sade, Y; Kara, NZ; et al. Beware of your mouse strain; differential effects of lithium on behavioral and neurochemical phenotypes in Harlan ICR mice bred in Israel or the USA. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124:36-39(2014).

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