Recombinant Human IMPA1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | IMPA1-770H |
Product Overview : | IMPA1 MS Standard C13 and N15-labeled recombinant protein (NP_005527) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Species : | Human |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Molecular Mass : | 30.2 kDa |
AA Sequence : | MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDEDTRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name | IMPA1 inositol monophosphatase 1 [ Homo sapiens (human) ] |
Official Symbol | IMPA1 |
Synonyms | IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1; IMP; |
Gene ID | 3612 |
mRNA Refseq | NM_005536 |
Protein Refseq | NP_005527 |
MIM | 602064 |
UniProt ID | P29218 |
◆ Recombinant Proteins | ||
IMPA1-841Z | Recombinant Zebrafish IMPA1 | +Inquiry |
IMPA1-770H | Recombinant Human IMPA1 Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
IMPA1-2824H | Recombinant Human IMPA1, His-tagged | +Inquiry |
Impa1-3529M | Recombinant Mouse Impa1 Protein, Myc/DDK-tagged | +Inquiry |
IMPA1-3056R | Recombinant Rat IMPA1 Protein | +Inquiry |
◆ Cell & Tissue Lysates | ||
IMPA1-5214HCL | Recombinant Human IMPA1 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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