Recombinant Human IL21, His-tagged

• Cat.No.: IL21-15H
• Product Overview: Recombinant Human Interleukin-21/IL-21 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln23-Ser155) of Human IL-21 fused with a polyhistidine tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Protein Length: 23-155 a.a.
• Description: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• AA Sequence: QGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNER IINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGS EDSVDHHHHHH
• Endotoxin: Less than 0.1 ng/µg (1 IEU/µg).
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Gene Information

• Gene Name: IL21 interleukin 21 [ Homo sapiens (human) ]
• Official Symbol: IL21
• Synonyms: IL21; interleukin 21; Za11; IL-21; CVID11; interleukin-21; interleukin-21 isoform
• Gene ID: 59067
• mRNA Refseq: NM_021803
• Protein Refseq: NP_068575
• MIM: 605384
• UniProt ID: Q9HBE4
• Chromosome Location: 4q26-q27
• Pathway: Cytokine-cytokine receptor interaction; Inflammatory bowel disease (IBD); Jak-STAT signaling pathway
• Function: cytokine activity; cytokine receptor binding; interleukin-2 receptor binding