Recombinant Human IDI1, His-tagged

• Cat.No.: IDI1-26060TH
• Product Overview: Recombinant full-length Human IDI1 with a N terminal His tag. 248 amino acids with a predicted MWt 28.6 kDa including tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 228 amino acids
• Description: IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol.It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
• Conjugation: HIS
• Molecular Weight: 28.600kDa inclusive of tags
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 10% Glycerol, 0.58% Sodium chloride
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMMPEINTNHLDKQQVQLLAE MCILIDENDNKIGAETKKNCHLNENIEKGLLHRAFSVF LFNTENKLLLQQRSDAKITFPGCFTNTCCSHPLSNPAELE ESDALGVRRAAQRRLKAELGIPLEEVPPEEINYLTRIH YKAQSDGIWGEHEIDYILLVRKNVTLNPDPNEIKSYCYVS KEELKELLKKAASGEIKITPWFKIIAATFLFKWWDNLN HLNQFVDHEKIYRM
• Sequence Similarities: Belongs to the IPP isomerase type 1 family.Contains 1 nudix hydrolase domain.

Gene Information

• Gene Name: IDI1 isopentenyl-diphosphate delta isomerase 1 [ Homo sapiens ]
• Official Symbol: IDI1
• Synonyms: IDI1; isopentenyl-diphosphate delta isomerase 1; isopentenyl diphosphate delta isomerase; isopentenyl-diphosphate Delta-isomerase 1; IPP isomerase
• Gene ID: 3422
• mRNA Refseq: NM_004508
• Protein Refseq: NP_004499
• MIM: 604055
• Uniprot ID: Q13907
• Chromosome Location: 10p15.3
• Pathway: C5 isoprenoid biosynthesis, mevalonate pathway, organism-specific biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, conserved biosystem; Cholesterol Biosynthesis, organism-specific biosystem; Cholesterol biosynthesis, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem
• Function: hydrolase activity; isomerase activity; isopentenyl-diphosphate delta-isomerase activity; metal ion binding