Recombinant Human IDI1, GST-tagged

• Cat.No.: IDI1-14052H
• Product Overview: Recombinant Human IDI1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-237a.a.
• Description: IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: IDI1 isopentenyl-diphosphate delta isomerase 1 [ Homo sapiens ]
• Official Symbol: IDI1
• Synonyms: IDI1; isopentenyl-diphosphate delta isomerase 1; isopentenyl diphosphate delta isomerase; isopentenyl-diphosphate Delta-isomerase 1; IPP isomerase; IPP isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; IPP1; IPPI1
• Gene ID: 3422
• mRNA Refseq: NM_004508
• Protein Refseq: NP_004499
• MIM: 604055
• UniProt ID: Q13907
• Chromosome Location: 10p15.3
• Pathway: C5 isoprenoid biosynthesis, mevalonate pathway, organism-specific biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, conserved biosystem; Cholesterol Biosynthesis, organism-specific biosystem; Cholesterol biosynthesis, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: hydrolase activity; isomerase activity; isopentenyl-diphosphate delta-isomerase activity; isopentenyl-diphosphate delta-isomerase activity; magnesium ion binding; manganese ion binding; metal ion binding