Recombinant Human HYAL2, His-tagged

• Cat.No.: HYAL2-14019H
• Product Overview: Recombinant Human HYAL2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5 UTR.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 99-448a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HYAL2 hyaluronoglucosaminidase 2 [ Homo sapiens ]
• Official Symbol: HYAL2
• Synonyms: HYAL2; hyaluronoglucosaminidase 2; hyaluronidase-2; hyaluronidase 2; LuCa 2; LUCA2; lysosomal hyaluronidase; PH 20 homolog; hyal-2; PH20 homolog; PH-20 homolog; lung carcinoma protein 2; hyaluronoglucosaminidase-2
• Gene ID: 8692
• mRNA Refseq: NM_003773
• Protein Refseq: NP_003764
• MIM: 603551
• UniProt ID: Q12891
• Chromosome Location: 3p21.3
• Pathway: Chondroitin sulfate degradation, organism-specific biosystem; Chondroitin sulfate degradation, conserved biosystem; Dermatan sulfate degradation, organism-specific biosystem; Dermatan sulfate degradation, conserved biosystem; Glycosaminoglycan degradation, organism-specific biosystem; Glycosaminoglycan degradation, conserved biosystem; Metabolic pathways, organism-specific biosystem
• Function: enzyme binding; hyaluronic acid binding; hyaluronoglucuronidase activity; hyalurononglucosaminidase activity; NOT hyalurononglucosaminidase activity; hydrolase activity, acting on glycosyl bonds; protein binding; receptor signaling protein tyrosine kinase