HYAL2

  • Official Full Name

    hyaluronoglucosaminidase 2

  • Overview

    This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5 UTR.[provided by RefSeq, Mar 2010]

  • Synonyms

    HYAL2;hyaluronoglucosaminidase 2;LUCA2;hyaluronidase-2;hyal-2;PH20 homolog;PH-20 homolog;hyaluronidase 2;lysosomal hyaluronidase;lung carcinoma protein 2;hyaluronoglucosaminidase-2

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • HEK293
  • Yeast
  • CHO
  • Wheat Germ
  • His
  • Non
  • His&Fc&Avi
  • GST
  • His&Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
HYAL2-14019H Recombinant Human HYAL2, His-tagged E.coli Human His 99-448a.a.
Hyal2-1172M Recombinant Mouse Hyal2 protein, His-tagged E.coli Mouse His Leu23~Gly447
HYAL2-2180R Recombinant Rhesus monkey HYAL2 Protein, His-tagged Mammalian Cell Rhesus macaque His
HYAL2-7953M Recombinant Mouse HYAL2 Protein Mammalian Cell Mouse His
HYAL2-5323HCL Recombinant Human HYAL2 293 Cell Lysate HEK293 Human Non
HYAL2-1651H Recombinant Human HYAL2 Protein (21-448 aa), His-tagged Yeast Human His 21-448 aa
HYAL2-2001R Recombinant Rhesus Macaque HYAL2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
HYAL2-2001R-B Recombinant Rhesus Macaque HYAL2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
HYAL2-301635H Recombinant Human ZHYAL2 protein, GST-tagged E.coli Human GST Gly99-Gly448
HYAL2-41H Active Recombinant Human HYAL2 Protein (Met21-Gly447), C-6×His-tagged CHO Human His Met21-Gly447
HYAL2-4389M Recombinant Mouse HYAL2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
HYAL2-4389M-B Recombinant Mouse HYAL2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
HYAL2-5221H Recombinant Human HYAL2 Protein, GST-tagged Wheat Germ Human GST
HYAL2-5938H Recombinant Human HYAL2 protein, His&Myc-tagged HEK293 Human His&Myc 21-448aa

    Involved Pathway

    HYAL2 involved in several pathways and played different roles in them. We selected most pathways HYAL2 participated on our site, such as Glycosaminoglycan degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan degradation HYAL6,NAGLU,HPSE,SGSH,HYAL4,HYAL3,ARSB,HEXA,GALNS,HYAL1
    Metabolic pathways PNLIPRP3,TREH,NANP,AMD1,PSAT1,GALNT3,ACSL4B,EARS2,HAAO,RRM2B

    Protein Function

    HYAL2 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity,enzyme binding,hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL2 itself. We selected most functions HYAL2 had, and list some proteins which have the same functions with HYAL2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription coactivator activity WBP2,PRRX1,SMARCA2,MKL1B,SOX11,PHF17,MED12,TFAP2B,PITX2,NEUROD1
    virus receptor activity EFNB3,SLC1A5,LDLR,CD209,SLAMF1,HAVCR1,NPC1,ITGB3,RPSA,NCAM1
    receptor tyrosine kinase binding NCK1,GAS6,SQSTM1,PLCG1,ZFP259,PIK3R2,SHC3,PTPN14,FIZ1,PITPNM3
    hyaluronoglucuronidase activity HYAL3
    protein binding MAPK13,CHMP2A,PARD6B,TECPR1,PIP,CHAC1,DOT1L,SPOPL,BRD8,HEXIM1
    transforming growth factor beta binding ENG,VASN,CD109,ACVRL1,TGFBR3,THBS1,LTBP1,ITGAV,TGFBR2,TGFB3
    hyaluronic acid binding CD44,BCAN,VCANB,VCAN,HAPLN1,NCAN,C1QBP,LYVE1,TNFAIP6,HAPLN4
    hyalurononglucosaminidase activity HYAL6,HYAL1,SPAM1,KIAA1199,CD44,HYAL3,HYAL4,MGEA5
    enzyme binding HIST1H2AE,PCCA,SIRT3,GBP1,CASP2,APP,GSTM2,RPA3,NCOA1,YWHAH

    Interacting Protein

    HYAL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL2.

    FHL3;KRTAP3-2;fadE;q5nii2_fratt;pepP;yqgS

    Resources

    References

    • Marei, WFA; Salavati, M; et al. Critical role of hyaluronidase-2 during preimplantation embryo development. MOLECULAR HUMAN REPRODUCTION 19:590-599(2013).
    • Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).
    • Li, LL; Asteriou, T; et al. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. BIOCHEMICAL JOURNAL 404:327-336(2007).
    • Selbi, W; de la Motte, C; et al. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. KIDNEY INTERNATIONAL 70:1287-1295(2006).

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    Q&As

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    Is the HYAL2-7953M Recombinant Mouse HYAL2 Protein a powder that you reconstitute and can add to a sample of HA and it digests it? or how does this work? 08/18/2023

    Protein Sequence: a.a.23-447; Host: E.coli; Lyophilized Powder; Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

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