Recombinant Human HSP90AB1, His-tagged

• Cat.No.: HSP90AB1-49H
• Product Overview: Recombinant Human HSP90AB1(Met1~Asp724), fused with N-terminal His-Tag, was expressed in E.coli.

Specification

• Description: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Molecular Mass: 85.5kDa
• AA Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.MGHHHHHHSGSEFELRRQ-MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKDDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEEYGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP NAAVPDEIPP LEGDEDASRM EEVD
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months.
• Protein length: 1-724 a.a.

Gene Information

• Gene Name: HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 [ Homo sapiens (human) ]
• Official Symbol: HSP90AB1
• Synonyms: HSP90AB1; heat shock protein 90kDa alpha (cytosolic), class B member 1; HSPC2; HSPCB; D6S182; HSP90B; FLJ26984; HSP90-BETA; heat shock 90kDa protein 1, beta; OTTHUMP00000016518; OTTHUMP00000016519; heat shock protein beta; Heat shock protein HSP 90-beta; HSP 90; HSP 84; OTTHUMP00000016517; OTTHUMP00000039869; heat shock 90kD protein 1, beta
• Gene ID: 3326
• mRNA Refseq: NM_007355
• Protein Refseq: NP_031381
• MIM: 140572
• UniProt ID: P08238
• Chromosome Location: 6p12
• Pathway: Antigen processing and presentation; NOD-like receptor signaling pathway; Pathways in cancer; Progesterone-mediated oocyte maturation; Prostate cancer
• Function: ATP binding; TPR domain binding; nitric-oxide synthase regulator activity; nucleotide binding; unfolded protein binding