HSP90AB1
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Official Full Name
heat shock protein 90kDa alpha (cytosolic), class B member 1 -
Overview
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding,;protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play;important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress.;There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive;form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM;606219) (Chen et al., 2005 (PubMed 16269234)). -
Synonyms
HSP90AB1;heat shock protein 90kDa alpha (cytosolic), class B member 1;heat shock 90kD protein 1, beta , heat shock 90kDa protein 1, beta , HSPC2, HSPCB;heat shock protein HSP 90-beta;heat shock 84 kDa;heat shock protein beta;heat shock 90kD protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- Cattle
- E.coli
- HEK293
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
HSP90AB1 involved in several pathways and played different roles in them. We selected most pathways HSP90AB1 participated on our site, such as Protein processing in endoplasmic reticulum,PIK-Akt signaling pathway,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP90AB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | WNT3,FGF7,WNT16,NTRK1,PTEN,PLCB4,ITGA2,CTNNA3,BIRC2,GNG2 |
| Progesterone-mediated oocyte maturation | CPEB1A,MAPK12B,PIK3CA,RAF1B,BUB1,MOS,HSP90AA1.1,RPS6KAL,CDK1,PIK3R3B |
| Prostate Cancer | AKT2,SPINK1,HSP90B1,NFKBIA,MAP4K1,PIK3R1,NOXA1,PIK3CA,PIK3R2,PDGFRB |
| Antigen processing and presentation | KIR2DL1,H2-AB1,CTSS,RFXANK,HLA-DOA,TAP2,KLRC3,CD8B1,NFYA,KLRC4 |
| PIK-Akt signaling pathway | IFNB1,LAMC2,GNGT1,IFNA17,PRLR,FGF21,NOS3,PPP2R5C,KITLG,TNR |
| Estrogen signaling pathway | MAPK1,PIK3CB,PIK3R1,RAF1,PLCB2,SHC1,KCNJ3,NOS3,CREB5,PRKACA |
| Protein processing in endoplasmic reticulum | WFS1,LMAN1,ERLEC1,HSPA1A,UBE2D1A,UBE2G2,MAN1A2,BAX,UBQLNL,HSC70 |
| NOD-like receptor signaling pathway | MAPK10,CARD8,NAIP6,CASP1,MAPK14B,MAPK12A,PYCARD,NAIP7,IL8L1,LOC100033925 |
Protein Function
HSP90AB1 has several biochemical functions, for example, ATP binding,CTP binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSP90AB1 itself. We selected most functions HSP90AB1 had, and list some proteins which have the same functions with HSP90AB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| UTP binding | MTPAP |
| ATP binding | ACSS3,DGKQ,CDK3,BTK,GSK3A,RECQL,NADSYN1,ADCY8,ABCD3A,HSPA12B |
| unfolded protein binding | HSP26,NPM1,DNAJA3B,HSP90AA1.2,HSPD1,HSP90AA1.1,SSUH2RS1,CALRL2,DNAJB2,DNAJA3 |
| TPR domain binding | HSP90AA1,PDE2A,RAB8B,STUB1 |
| dATP binding | ST13,ERCC3 |
| GTP binding | RAP2B,IRGQ2,HRASB,RRAD,REM1,RP2,SEPT9,GNA11A,TUBB6,MXE |
| protein binding | LTBP1,MARK4,NFKBIE,ZNF79,CNTNAP1,TMEM106B,FGF21,XPO6,PDE4C,HSPA13 |
| MHC class II protein complex binding | MS4A1,HLA-DRA,HLA-DMA,HLA-DOA,ATP1B1,HSPA8,HLA-DMB,HSP90AA1,CD81,YWHAE |
| kinase binding | TENC1,CHP1,C2orf44,SP100,CDC37,CTNNB1,TRIP6,CHIA,STRADA,CDC6 |
Interacting Protein
HSP90AB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP90AB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP90AB1.
EGFR;CDC37;CDC37L1
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References
- Sun, Y; Biscarini, F; et al. Genetic parameters and across-line SNP associations differ for natural antibody isotypes IgM and IgG in laying hens. ANIMAL GENETICS 44:413-424(2013).
