Recombinant Human HNRNPA2B1 Protein (Arg21-Gly103), His tagged

• Cat.No.: HNRNPA2B1-3085H
• Product Overview: Recombinant human HNRNPA2B1 (Arg21-Gly103) protein fused with His tag was expressed in E. coli.

Specification

• Description: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear' reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A) -containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs. Plays also a role in the activation of the innate immune response. Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6. In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 11.58 kDa
• Protein length: Arg21-Gly103
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Lyophilized from PBS pH 7.4, 0.02 % NLS, 1mM EDTA, 4 % trehalose, 1 % mannitol.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Homo sapiens (human) ]
• Official Symbol: HNRNPA2B1
• Synonyms: HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1; HNRPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein; RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; FLJ22720; DKFZp779B0244
• Gene ID: 3181
• mRNA Refseq: NM_002137
• Protein Refseq: NP_002128
• MIM: 600124
• UniProt ID: P22626

Reviews

08/29/2022

Top-notch analysis, a critical component of our research.

12/24/2021

Precision in results, a trusted source of research data.

07/07/2017

Expertise shines, a dependable research collaborator.

Q&As

How does HNRNPA2B1 contribute to mRNA splicing?

It influences mRNA splicing, affecting transcript diversity.

How do genetic variations in HNRNPA2B1 affect RNA metabolism?

Genetic mutations in HNRNPA2B1 impact RNA splicing and processing.

What is the primary role of HNRNPA2B1 in RNA processing?

HNRNPA2B1 is key for RNA processing and metabolism.

How does HNRNPA2B1 interact with other RNA-binding proteins?

HNRNPA2B1 works with RNA-binding proteins to manage RNA regulation.

What is the impact of altered HNRNPA2B1 activity on neurodegenerative diseases?

Altered HNRNPA2B1 activity is linked to neurodegenerative conditions.

What role does HNRNPA2B1 play in gene regulation?

HNRNPA2B1 regulates gene expression at the RNA level.

What potential therapeutic applications arise from targeting HNRNPA2B1 in RNA-based disorders?

Targeting HNRNPA2B1 could treat RNA processing-related diseases.