HNRNPA2B1

What is HNRNPA2B1 Protein?

HNRNPA2B1 is a protein that might not have a catchy name, but it does some important work inside your cells. It helps manage RNA, which is kind of like the instruction manual for building proteins. Beyond just shuffling RNA around, HNRNPA2B1 is involved in various cell activities, such as how cells use energy, grow, move, and even decide when to die. Think of it as a multitasker, keeping things running smoothly behind the scenes. Some studies are looking into how it's linked to certain diseases, especially those involving cell damage, because it can influence inflammation and other vital processes. So, while it might not be the star of the show, HNRNPA2B1 plays a supporting role that's crucial for cell health.

What is the Function of HNRNPA2B1 Protein?

HNRNPA2B1 is a kind of all-purpose tool inside cells. Its primary gig is working with RNA, the stuff that translates DNA's instructions into proteins. This protein helps get RNA ready and moves it where it's needed, making sure proteins are made correctly and on time. But that's not all—it also helps manage the cell's energy use, supports cell growth, assists in cell movement, and figures into the process of cells dying when they're damaged or just not needed anymore. This makes it pretty vital for keeping cell operations smooth. Scientists are checking out how it might be involved in various diseases, especially when things in the cell go haywire. So, HNRNPA2B1 is essential for keeping the cellular chaos in check.

HNRNPA2B1 Related Signaling Pathway

HNRNPA2B1 is key in some important signaling pathways that keep cells running smoothly. One of its main tasks is regulating RNA, which is crucial for making proteins. But what’s interesting is how it ties into signaling pathways. This protein is part of the way cells communicate and make decisions, impacting things like cell growth and response to stress. For instance, it can affect pathways that control inflammation, which is a big deal in many diseases. It’s also connected to how cells use energy, which links to metabolism. When pathways involving HNRNPA2B1 get thrown off balance, it might contribute to problems like cancer or neurodegenerative disorders. Researchers are digging into these signaling pathways to see how altering HNRNPA2B1 might help in treating these conditions. So, while it works behind the scenes, HNRNPA2B1 plays a vital role in cell signaling and overall health.

HNRNPA2B1 Related Diseases

HNRNPA2B1 isn’t the star of the show, but it has a hand in several diseases because of its critical role in cell function. When things go wrong with this protein, it can lead to trouble. It’s involved in neurological disorders, like ALS and some forms of dementia, because it affects how nerve cells handle stress and damage. In cancer, changes in HNRNPA2B1 can mess with cell growth signals, leading to unchecked tumor development. It’s also linked to problems with inflammation, impacting diseases where the immune system doesn't quite work right. Researchers are trying to understand exactly how HNRNPA2B1 influences these conditions, hoping that targeting it could offer new treatment options. So, while it may not be famous, HNRNPA2B1 has a big impact on health when things go sideways.

Bioapplications of HNRNPA2B1

HNRNPA2B1 might not be a household name, but it has some exciting potential in biotechnology and medicine. Because it's deeply involved in how cells process RNA and regulate themselves, it’s being studied for its role in various diseases. Scientists think that by understanding and maybe tweaking how HNRNPA2B1 works, we could develop new ways to treat conditions like cancer and neurodegenerative diseases. It could help create therapies that adjust cell growth or enhance nerve cell survival. Plus, exploring this protein might lead to better diagnostic tools, helping to identify diseases earlier based on changes in how HNRNPA2B1 functions. So, even though it's not the star player, HNRNPA2B1 holds a lot of promise for future medical breakthroughs.

Case Study 1: Petri BJ. et al. Cancer Lett. 2021

New treatments help ER+ breast cancer patients, but resistance issues remain. We've noted that the protein HNRNPA2B1 (A2B1) is higher in tamoxifen-resistant cells and tumors. When overproduced in MCF-7 cells, A2B1 causes drug resistance and aggressive behavior. Knocking down A2B1 reverses this resistance. These changes involve increased cancer stem cell traits and active protein pathways, which can be targeted with inhibitors.

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  Fig1. A2B1 protein levels were measured.
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  Fig2. Representative western blot for A2B1 knockdown in T47D cells.

Case Study 2: Chen Y. et al. Mediators Inflamm. 2020

The protein hnRNPA2/B1 is involved in RNA and cell processes, but its role in damaged endothelial cells is unclear. We studied how it affects cells exposed to LPS, which harms human vein endothelial cells. When hnRNPA2/B1 is lowered, these cells become more permeable and inflamed. Raising hnRNPA2/B1, however, makes them less leaky and reduces inflammation, while boosting those proteins involved in cell junctions. Lowering hnRNPA2/B1 also increases activation of NF-κB and affects the VE-cadherin/β-catenin pathway after LPS exposure.

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  Fig3. hnRNPA2/B1 protein levels were measured by Western blotting.
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  Fig4. Effect of hnRNPA2/B1 knockdown on LPS-induced NF-κB signaling activation.

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  Fig1. A model of how upregulation of HNRNPA2B1 may contribute to TAM-resistant (TAM-R) breast cancer. (Belinda J Petri, 2021)
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  Fig2. Working model of hnRNPA2/B1 as a negative regulator of human breast cancer metastasis. (Yu Liu, 2020)

HNRNPA2B1 has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPA2B1 itself. We selected most functions HNRNPA2B1 had, and list some proteins which have the same functions with HNRNPA2B1. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	UPF3A,HNRNPL2,CAPRIN2,ALYREF,RPL14,IFIT12,CPSF1,RBM3,CPEB3,RBMX
nucleotide binding	TSSK5,PTK2AB,PUF60,RTEL1,CDC42L2,TUBA8L,RBM4.1,SYNJ1,AKT2L,PSPC1
pre-mRNA intronic binding	PRPF8,RNPC3,EP300,RBM41,RBM4,SOX9
poly(A) RNA binding	SMC1A,PPP1CC,SAMD4A,DHX36,FASTKD1,RBM3,WDR3,HRSP12,SNRPD3,UBE2I
single-stranded telomeric DNA binding	POT1A,POT1,OBFC1
protein binding	MAPK12,AGPAT5,PIP4K2B,MYO7B,CDK11B,KXD1,SIX3,MED26,NCKIPSD,VRK2

HNRNPA2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPA2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPA2B1.

GRB2;YBX1;ZMAT3;TOP1;Prnp;ACTB;MAX;VLTF3;DHX9;SF3A2;HSPB1;h5_vaccw;NR4A1