HNRNPA2B1
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Official Full Name
heterogeneous nuclear ribonucleoprotein A2/B1
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Overview
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1; RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; IBMPFD2; HNRPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- C
- hFc
- His
- Flag
- GST
- B2M
- Fc
- Avi
- Myc
- SUMO
- DDK
- N
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
HNRNPA2B1 involved in several pathways and played different roles in them. We selected most pathways HNRNPA2B1 participated on our site, such as Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPA2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | AGO3B;MED23;COX16;LAMTOR1;DCP1B;NR1I3;ZNF740;TTC6;ZNF224 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPUL1;CD2BP2;YBX1;HNRNPA0B;HNRNPA0L;HNRNPR;HNRNPD;PAPOLA;SFRS3A |
| mRNA Splicing | CD2BP2;HNRNPA0A;ZMAT5;HNRNPL;SF3A3;SF3B2;HNRNPA2B1;HNRNPL2;RNPC3 |
| mRNA Splicing - Major Pathway | PTBP1B;CD2BP2;SUGP1;BCAS2;HNRNPF;HNRNPD;SF3B4;HNRNPH2;PRPF8 |
| mRNA processing | SFRS3A;LOC100862398;SF3B4;PRPF8;SUGP2;FAM120B;SRSF10;RAVER1;CLK3 |
HNRNPA2B1 has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPA2B1 itself. We selected most functions HNRNPA2B1 had, and list some proteins which have the same functions with HNRNPA2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | RPL7A;SRSF10;CELF2;ELAVL1;HNRPL;HDLBPA;CPEB3;PTBP1;NABP1 |
| nucleotide binding | PCXA;CIRBPA;RAB34A;SART3;CLCN4-2;EIF3BA;MAT2AA;TUBA2;RND3B |
| poly(A) RNA binding | DZIP3;TUFM;CSTF2;MRPL28;NXF1;PRAC;LSM14A;RBM47;TRAP1 |
| pre-mRNA intronic binding | HNRNPA2B1;SOX9;PRPF8;RNPC3;EP300;RBM4;RBM41 |
| protein binding | MAP2;SYT11;MOB4;MRAP;CDC73;CHIC2;KCNA2;RIMS1;CRYBB3 |
| single-stranded telomeric DNA binding | POT1;POT1A;HNRNPA2B1;OBFC1 |
HNRNPA2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPA2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPA2B1.
GRB2; YBX1; ZMAT3; TOP1; Prnp; ACTB; MAX; VLTF3; DHX9; SF3A2; HSPB1; h5_vaccw; NR4A1
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Q&As (7)
Ask a questionIt influences mRNA splicing, affecting transcript diversity.
Genetic mutations in HNRNPA2B1 impact RNA splicing and processing.
HNRNPA2B1 is key for RNA processing and metabolism.
HNRNPA2B1 works with RNA-binding proteins to manage RNA regulation.
Altered HNRNPA2B1 activity is linked to neurodegenerative conditions.
HNRNPA2B1 regulates gene expression at the RNA level.
Targeting HNRNPA2B1 could treat RNA processing-related diseases.
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