Recombinant Human HMOX1, His-tagged

Cat.No. : HMOX1-27877TH
Product Overview : Recombinant fragment corresponding to amino acids 1-266 of Human Heme Oxygenase 1 fused to His tag at C-terminus; 274 amino acids, 31.4 kDa.
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Species : Human
Source : E.coli
Tag : His
Protein Length : 1-266 a.a.
Description : Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
Conjugation : HIS
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 0.1mM PMSF, pH 8
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MERPQPHSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQLYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN TRSQAPLEHH HHHH
Sequence Similarities : Belongs to the heme oxygenase family.
Gene Name HMOX1 heme oxygenase (decycling) 1 [ Homo sapiens ]
Official Symbol HMOX1
Synonyms HMOX1; heme oxygenase (decycling) 1; heme oxygenase 1; bK286B10; HO 1;
Gene ID 3162
mRNA Refseq NM_002133
Protein Refseq NP_002124
MIM 141250
Uniprot ID P09601
Chromosome Location 22q12
Pathway HIF-1-alpha transcription factor network, organism-specific biosystem; Heme degradation, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Keap1-Nrf2 Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function enzyme binding; heme binding; heme oxygenase (decyclizing) activity; heme oxygenase (decyclizing) activity; metal ion binding;

Not For Human Consumption!

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