Recombinant Human HLA-DMA protein, His-tagged

• Cat.No.: HLA-DMA-4026H
• Product Overview: Recombinant Human HLA-DMA protein(Q6ICR9)(27-233aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 27.4 kDa
• Protein length: 27-233aa
• AA Sequence: VPEAPTPMWPDDLQNHTFLHTVYCQ DGSPSVGLSEAYDEDQLFFFDFSQN TRVPRLPEFADWAQEQGDAPAILFD KEFCEWMIQQIGPKLDGKIPVSRGF PIAEVFTLKPLEFGKPNTLVCFVSN LFPPMLTVNWQHHSVPVEGFGPTFV SAVDGLSFQAFSYLNFTPEPSDIFS CIVTHEIDRYTAIAYWVPRNALPSD LLENVLC
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: HLA-DMA major histocompatibility complex, class II, DM alpha [ Homo sapiens ]
• Official Symbol: HLA-DMA
• Synonyms: HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA; really interesting new gene 6 protein; class II histocompatibility antigen, M alpha chain; DMA; HLADM
• Gene ID: 3108
• mRNA Refseq: NM_006120
• Protein Refseq: NP_006111
• MIM: 142855
• UniProt ID: P28067

Reviews

08/17/2021

Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.

06/20/2016

Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.

04/04/2016

Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.

Q&As

How does HLA-DMA relate to autoimmune diseases?

Aberrant antigen presentation mediated by HLA-DMA has been implicated in autoimmune diseases, as it may lead to the presentation of self-antigens and the activation of autoreactive T cells.

How can HLA-DMA be a potential therapeutic target?

Modulating HLA-DMA activity could be explored as a therapeutic strategy in conditions where immune dysregulation occurs, such as autoimmune diseases, by influencing antigen presentation.

How does HLA-DMA contribute to the adaptive immune response?

HLA-DMA facilitates the loading of antigenic peptides onto MHC class II molecules, a process essential for the activation of CD4+ T cells and the adaptive immune response.

In transplantation, how does HLA-DMA impact graft acceptance or rejection?

Understanding HLA-DMA's role is crucial in transplantation, as it affects the presentation of antigens from the graft, influencing the immune response and the likelihood of graft acceptance or rejection.

Are there genetic variations in HLA-DMA that can influence disease susceptibility?

Genetic variations in the HLA-DMA gene may contribute to differences in antigen presentation and influence susceptibility to certain diseases, making it an area of interest in genetic studies.