Recombinant Human GRK2 Protein, His/GST-tagged

• Cat.No.: GRK2-386H
• Product Overview: Recombinant Human GRK2(Asp398~Leu640) fused with His/GST tag at N-terminal was expressed in E. coli.

Specification

• Description: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
• Source: E. coli
• Species: Human
• Tag: His&GST
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 60.7kDa
• Protein length: Asp398~Leu640
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens ]
• Official Symbol: GRK2
• Synonyms: BARK1; ADRBK1; BETA-ARK1; adrenergic beta receptor kinase 1; beta-ARK-1
• Gene ID: 156
• mRNA Refseq: NM_001619
• Protein Refseq: NP_001610
• UniProt ID: P25098