Recombinant Human GRK2 Protein (Asp398-Leu640), N-GST tagged

• Cat.No.: GRK2-2999H
• Product Overview: Recombinant human GRK2 (Asp398-Leu640) protein fused with the N-GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
• Source: E. coli
• Species: Human
• Tag: GST
• Molecular Mass: 55.13 kDa
• Protein length: Asp398-Leu640
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens (human) ]
• Official Symbol: GRK2
• Synonyms: GRK2; G protein-coupled receptor kinase 2; BARK1; ADRBK1; BETA-ARK1; beta-adrenergic receptor kinase 1; adrenergic beta receptor kinase 1; beta-ARK-1; EC 2.7.11.15
• Gene ID: 156
• mRNA Refseq: NM_001619
• Protein Refseq: NP_001610
• MIM: 109635
• UniProt ID: P25098