Recombinant Human gremlin 2, DAN family BMP antagonist, His-tagged

• Cat.No.: GREM2-534H
• Product Overview: GREM2, 22-168aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 22-168 a.a.
• Description: GREM2 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this protein belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this protein may play a role in regulating organogenesis, body patterning, and tissue differentiation. Recombinant human GREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 19 kDa (170aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSRKNRPAG AIPSPYKDGS SNNSERWQHQ IKEVLASSQE ALVVTERKYL KSDWCKTQPL RQTVSEEGCR SRTILNRFCY GQCNSFYIPR HVKKEEESFQ SCAFCKPQRV TSVLVELECP GLDPPFRLKK IQKVKQCRCM SVNLSDSDKQ
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: GREM2 gremlin 2 [ Homo sapiens ]
• Official Symbol: GREM2
• Synonyms: GREM2; gremlin 2; gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-2; CKTSF1B2; DAND3; FLJ21195; Prdc; protein related to DAN and cerberus; DAN domain family member 3; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; PRDC
• Gene ID: 64388
• mRNA Refseq: NM_022469
• Protein Refseq: NP_071914
• MIM: 608832
• UniProt ID: Q9H772
• Chromosome Location: 1q43
• Pathway: Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem
• Function: cytokine activity