GREM2
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Official Full Name
gremlin 2 -
Overview
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. -
Synonyms
GREM2;gremlin 2;gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis);gremlin-2;CKTSF1B2;DAND3;FLJ21195;Prdc;protein related to DAN and cerberus;Cysteine knot superfamily 1 BMP antagonist 2;DAN domain family member 3;DAND 3;GREM 2;Gremlin 2 cysteine knot superfamily homolog;Gremlin2;cysteine knot superfamily 1, BMP antagonist 2;gremlin 2, cysteine knot superfamily, homolog
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Human
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GREM2 involved in several pathways and played different roles in them. We selected most pathways GREM2 participated on our site, such as Signal Transduction,Signaling by BMP, which may be useful for your reference. Also, other proteins which involved in the same pathway with GREM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by BMP | NOG1,CALML4,NOG,FSTL1A,SKIB,FSTL1B,FSTL1,SKIA,CHRDL1 |
| Signal Transduction | LPAR5A,RGS12,FST,RGS14,ROR2,BCO2L,TNKS,OPN1LW2,RPE65A,ZFPM2B |
Protein Function
GREM2 has several biochemical functions, for example, BMP binding,cytokine activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GREM2 itself. We selected most functions GREM2 had, and list some proteins which have the same functions with GREM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BMP binding | GDF5,BMPR2,GREM1,HFE2,NBL1,CER1,TCAP |
| cytokine activity | Fasl,TXLNA,LFT2,IFNA3,TNFSF13,Ifnl2,IL17B,TNFSF8,CCL38A.4,Ctf2 |
| protein homodimerization activity | RPE,NACC2,CBLN1,MASP1,Pdgfa&Pdgfb,UGT1A4,TKT,RPL7,GPD1L,MGLL |
| heparin binding | HSD17B12,PTPRF,NRP1,CCL2,F11,MPO,NELL2,LIPG,ANG,ZNF207 |
Interacting Protein
GREM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GREM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GREM2.
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