Recombinant Human GPLD1

• Cat.No.: GPLD1-27985TH
• Product Overview: Recombinant full length Human GPLD1 Isoform 2 with N terminal proprietary tag; Predicted MW 45.47 kDa.

Specification

• Description: Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
• Protein length: 176 amino acids
• Molecular Weight: 45.470kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSAFRLWPGLLIMLGSLCHRGSPCGLSTHIEIGHRALEFL QLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKF HDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLF GITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSA GDFGTVYLHLLNFLVV
• Sequence Similarities: Belongs to the GPLD1 family.Contains 7 FG-GAP repeats.
• Tag: Non

Gene Information

• Gene Name: GPLD1 glycosylphosphatidylinositol specific phospholipase D1 [ Homo sapiens ]
• Official Symbol: GPLD1
• Synonyms: GPLD1; glycosylphosphatidylinositol specific phospholipase D1; phosphatidylinositol-glycan-specific phospholipase D
• Gene ID: 2822
• mRNA Refseq: NM_001503
• Protein Refseq: NP_001494
• MIM: 602515
• Uniprot ID: P80108
• Chromosome Location: 6p22.1
• Pathway: Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, organism-specific biosystem; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, conserved biosystem
• Function: glycosylphosphatidylinositol phospholipase D activity; hydrolase activity; phospholipase D activity

Reviews

12/29/2022

Swift and accurate service, essential for research progress.

10/20/2022

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09/23/2021

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Q&As

How does GPLD1 interact with other enzymes in carbohydrate and lipid metabolism?

GPLD1 works with other metabolic enzymes, coordinating carbohydrate and lipid metabolism.

What potential therapeutic applications arise from targeting GPLD1 in metabolic diseases?

Targeting GPLD1 offers potential in treating metabolic disorders by regulating liver metabolism.

What role does GPLD1 play in lipid metabolism?

GPLD1 is also involved in lipid metabolism, affecting fat processing and storage.

What is the impact of altered GPLD1 activity on metabolic disorders?

Altered GPLD1 activity is linked to various metabolic disorders, including diabetes and liver diseases.

What is the primary role of GPLD1 in liver function?

GPLD1, a glycosylphosphatidylinositol-specific phospholipase, is involved in modulating liver metabolism and function.

How do genetic variations in GPLD1 affect liver health?

Genetic variations in GPLD1 can lead to altered metabolic processing, impacting liver health and function.

How does GPLD1 contribute to glycogen metabolism?

It plays a role in glycogen metabolism, impacting glucose regulation in the liver.