Recombinant Human GPLD1, His-tagged

• Cat.No.: GPLD1-13427H
• Product Overview: Recombinant Human GPLD1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-176a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GPLD1 glycosylphosphatidylinositol specific phospholipase D1 [ Homo sapiens ]
• Official Symbol: GPLD1
• Synonyms: GPLD1; glycosylphosphatidylinositol specific phospholipase D1; phosphatidylinositol-glycan-specific phospholipase D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D; glycoprotein phospholipase D; phospholipase D, phosphatidylinositol-glycan-specific; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1; MGC22590
• Gene ID: 2822
• mRNA Refseq: NM_001503
• Protein Refseq: NP_001494
• MIM: 602515
• UniProt ID: P80108
• Chromosome Location: 6p22.1
• Pathway: Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, organism-specific biosystem; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, conserved biosystem
• Function: glycosylphosphatidylinositol phospholipase D activity; glycosylphosphatidylinositol phospholipase D activity; hydrolase activity; phospholipase C activity; phospholipase D activity; sodium channel regulator activity; zinc ion binding

Reviews

12/29/2022

Swift and accurate service, essential for research progress.

10/20/2022

Invaluable support for insights, a research necessity.

09/23/2021

Trustworthy results, accelerates our research success.

Q&As

How does GPLD1 interact with other enzymes in carbohydrate and lipid metabolism?

GPLD1 works with other metabolic enzymes, coordinating carbohydrate and lipid metabolism.

What potential therapeutic applications arise from targeting GPLD1 in metabolic diseases?

Targeting GPLD1 offers potential in treating metabolic disorders by regulating liver metabolism.

What role does GPLD1 play in lipid metabolism?

GPLD1 is also involved in lipid metabolism, affecting fat processing and storage.

What is the impact of altered GPLD1 activity on metabolic disorders?

Altered GPLD1 activity is linked to various metabolic disorders, including diabetes and liver diseases.

What is the primary role of GPLD1 in liver function?

GPLD1, a glycosylphosphatidylinositol-specific phospholipase, is involved in modulating liver metabolism and function.

How do genetic variations in GPLD1 affect liver health?

Genetic variations in GPLD1 can lead to altered metabolic processing, impacting liver health and function.

How does GPLD1 contribute to glycogen metabolism?

It plays a role in glycogen metabolism, impacting glucose regulation in the liver.