Recombinant Human GFRAL Protein, 19-351, N-Fc tagged

• Cat.No.: GFRAL-001H
• Product Overview: The extracellular domain of human GFRAL (aa 19-351) fused to the N-terminus of the Fc region of human IgG1 was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 19-351 a.a.
• Description: Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in glial cell-derived neurotrophic factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of protein kinase B signaling. Located in external side of plasma membrane.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: ~50-100 kDa
• Endotoxin: <1 EU/mg purified protein (LAL test; Lonza).
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Storage: Short Term Storage: +4 centigrade
  Long Term Storage: -20 centigrade
• Storage Buffer: Lyophilized from 0.2μm-filtered solution in PBS.
• Shipping: BLUE ICE
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.

Gene Information

• Gene Name: GFRAL GDNF family receptor alpha like [ Homo sapiens (human) ]
• Official Symbol: GFRAL
• Synonyms: GFRAL; GDNF family receptor alpha like; GRAL; UNQ9356; C6orf144; bA360D14.1; GDNF family receptor alpha-like; IVFI9356
• Gene ID: 389400
• mRNA Refseq: NM_207410
• Protein Refseq: NP_997293
• MIM: 617837
• UniProt ID: Q6UXV0