Recombinant Human GABARAP Protein, GST-tagged

• Cat.No.: GABARAP-937H
• Product Overview: Recombinant human GABARAP protein, fused to GST tag at N-terminus, was expressed in E. coli.

Specification

• Description: Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Lyophilized from a 0.2 µM filtered solution of 50 mM Tris.HCl, 200 mM NaCl, pH 7.5
• Molecular Mass: 40.21kD
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Gene Information

• Gene Name: GABA type A receptor-associated protein[ Homo sapiens ]
• Official Symbol: GABARAP
• Synonyms: ATG8A; GABARAP-a; MM46
• Gene ID: 11337
• mRNA Refseq: NM_007278.1
• Protein Refseq: NP_009209
• MIM: 605125
• UniProt ID: O95166

Reviews

09/10/2020

Precise protein quantification, fundamental for our studies' accuracy.

08/20/2020

Efficient protein purification, consistent yields, cost-effective service.

05/15/2020

Dependable peptide synthesis, accelerates our peptide-based projects.

Q&As

What are the mechanisms by which GABARAP modulates protein aggregation and degradation in cells?

GABARAP contributes to protein aggregation and degradation processes, crucial in maintaining cellular health.

How does GABARAP influence the trafficking and surface expression of GABA receptors?

GABARAP impacts GABA receptor trafficking and surface expression, affecting receptor availability and signaling.

What is the impact of GABARAP on immune cell function and inflammatory responses?

GABARAP plays a role in immune cell functioning and modulates inflammatory responses.

How does GABARAP participate in the process of autophagy and cellular homeostasis?

GABARAP is involved in autophagy, aiding in the degradation and recycling of cellular components for homeostasis.

How does GABARAP contribute to the pathophysiology of neurological disorders, such as Alzheimer's disease?

GABARAP is linked to the pathology of neurological disorders, potentially affecting protein aggregation and neuronal function.

What role does GABARAP play in neuronal signaling and the regulation of GABAergic synapses?

GABARAP regulates neuronal signaling, particularly at GABAergic synapses, influencing neurotransmission.

How do alterations in GABARAP expression or function affect cancer cell growth and survival?

Changes in GABARAP expression influence cancer cell behavior, impacting growth, survival, and responsiveness to therapy.