Recombinant Human GABARAP, GST-tagged

• Cat.No.: GABARAP-13085H
• Product Overview: Recombinant Human GABARAP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-117a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GABARAP GABA(A) receptor-associated protein [ Homo sapiens ]
• Official Symbol: GABARAP
• Synonyms: GABARAP; GABA(A) receptor-associated protein; gamma-aminobutyric acid receptor-associated protein; ATG8A; MM46; GABARAP-a; FLJ25768; MGC120154; MGC120155
• Gene ID: 11337
• mRNA Refseq: NM_007278
• Protein Refseq: NP_009209
• MIM: 605125
• UniProt ID: O95166
• Chromosome Location: 17p13.1
• Pathway: GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem
• Function: GABA receptor binding; beta-tubulin binding; microtubule binding; protein binding

Reviews

09/10/2020

Precise protein quantification, fundamental for our studies' accuracy.

08/20/2020

Efficient protein purification, consistent yields, cost-effective service.

05/15/2020

Dependable peptide synthesis, accelerates our peptide-based projects.

Q&As

What are the mechanisms by which GABARAP modulates protein aggregation and degradation in cells?

GABARAP contributes to protein aggregation and degradation processes, crucial in maintaining cellular health.

How does GABARAP influence the trafficking and surface expression of GABA receptors?

GABARAP impacts GABA receptor trafficking and surface expression, affecting receptor availability and signaling.

What is the impact of GABARAP on immune cell function and inflammatory responses?

GABARAP plays a role in immune cell functioning and modulates inflammatory responses.

How does GABARAP participate in the process of autophagy and cellular homeostasis?

GABARAP is involved in autophagy, aiding in the degradation and recycling of cellular components for homeostasis.

How does GABARAP contribute to the pathophysiology of neurological disorders, such as Alzheimer's disease?

GABARAP is linked to the pathology of neurological disorders, potentially affecting protein aggregation and neuronal function.

What role does GABARAP play in neuronal signaling and the regulation of GABAergic synapses?

GABARAP regulates neuronal signaling, particularly at GABAergic synapses, influencing neurotransmission.

How do alterations in GABARAP expression or function affect cancer cell growth and survival?

Changes in GABARAP expression influence cancer cell behavior, impacting growth, survival, and responsiveness to therapy.