Recombinant Human FST, His-tagged

• Cat.No.: FST-27459TH
• Product Overview: Recombinant full-length Human Follistatin with N-Terminal His tag.Mol Wt 36 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 315 amino acids
• Description: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release.The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA.In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
• Conjugation: HIS
• Molecular Weight: 36.000kDa
• Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
• Form: Lyophilised:Add deionized water (200 μl) to prepare a working stock solution of approximately 0.5 mg/mL
• Purity: by SDS-PAGE
• Storage buffer: pH: 7.50Constituents:0.24% Tris, 0.116% Sodium chloride
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MKHHHHHHAS GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCNSI SEDTEEEEED EDQDYSFPIS SILEW
• Sequence Similarities: Contains 3 follistatin-like domains.Contains 3 Kazal-like domains.Contains 1 TB (TGF-beta binding) domain.

Gene Information

• Gene Name: FST follistatin [ Homo sapiens ]
• Official Symbol: FST
• Synonyms: FST; follistatin; FS
• Gene ID: 10468
• mRNA Refseq: NM_006350
• Protein Refseq: NP_006341
• MIM: 136470
• Uniprot ID: P19883
• Chromosome Location: 5q11.2
• Pathway: BMP receptor signaling, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem
• Function: activin binding; heparan sulfate proteoglycan binding; protein binding; signal transducer activity