FST
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Official Full Name
follistatin -
Overview
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008] -
Synonyms
FST;follistatin;FS;activin-binding protein;follistatin isoform FST317
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Horse
- HEK293
- E.coli
- Insect Cells
- S.frugiperda
- CHO
- Nicotiana Benthamiana
- Sf21 Cells
- Mammalian Cells
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- Fc
- Non
- His
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FST involved in several pathways and played different roles in them. We selected most pathways FST participated on our site, such as Antagonism of Activin by Follistatin,BMP receptor signaling,Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BMP receptor signaling | SOSTDC1,CTDSPL,NOG,RGMB,RGMA,CALML4,CTDSP2,CHRDL1,SKI,HFE2 |
| TGF Beta Signaling Pathway | NOG,LEFTY1,TGFBR3,RUNX3,ZFP423,FOXH1,ENG,ZNF423 |
| Signal Transduction | PDK3B,ARHGAP22,OPN5,SDR9C7,NEDD8,SKIB,PTPRK,FGD4,ADH8A,JUPA |
| TGF-beta signaling pathway | RPS6KB2,BAMBIB,LEFTY1,TGFBR1A,BMP8A,ACVR2AA,RHOAC,ACVR2B,IFNG,SMAD7B |
| Antagonism of Activin by Follistatin | FSTL3,INHBAA,FSTB |
| Integrated Pancreatic Cancer Pathway | WRN,MST1,CST3,CASP12,GPRC5A,MYT1,CD82,TFF1,DAXX,BRF1 |
| Signaling by Activin | DRAP1,FSTL3,FOXH1,INHBAA,ACVR1C,FSTB |
Protein Function
FST has several biochemical functions, for example, activin binding,heparan sulfate proteoglycan binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FST itself. We selected most functions FST had, and list some proteins which have the same functions with FST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| activin binding | SMURF1,ACVRL1,SMAD7,FSTL3,FKBP1A,TGFBR3,ACVR1,ACVR2B,ENG |
| signal transducer activity | CXCR2,STAT2,TAAR13E,OMPB,TRIM13,GPR139,STAT4,PTGER4A,NPY8BR,ADRB3A |
| heparan sulfate proteoglycan binding | GPC1,Itgam&Itgb2,SEMA5A,COMP,SLIT2,GPC6A,GPC3,HRG,GPC1A,GPC4 |
| protein binding | TUBGCP4,SNTB1,MAFG,FZD3,PRPSAP1,RSPH1,FBXL19,FKBP4,BHLHE40,DZIP1L |
Interacting Protein
FST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FST here. Most of them are supplied by our site. Hope this information will be useful for your research of FST.
ANG;DIP2A;Mstn;ADAM12;ADAM8;FSTL1;TK1;MEST;C8orf33
Resources
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References
- Chen, FF; Ren, P; et al. Follistatin Is a Novel Biomarker for Lung Adenocarcinoma in Humans. PLOS ONE 9:-(2014).
- Gokmen-Polar, Y; Goswami, CP; et al. Gene Expression Analysis Reveals Distinct Pathways of Resistance to Bevacizumab in Xenograft Models of Human ER-Positive Breast Cancer. JOURNAL OF CANCER 5:633-645(2014).
