Recombinant Human FOXA2

• Cat.No.: FOXA2-28944TH
• Product Overview: Recombinant full length Human FOXA2; amino acids 1-457, MWt 48.3kDa.

Specification

• Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
• Molecular Weight: 48.300kDa
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 500mM L-arginine, 300mM Guanidine-HCl, 50mM HEPES, 5mM Cystamine, 5mM Cysteamine, 5mM Calcium chloride, 3mM DTT, pH 7.5
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 fork-head DNA-binding domain.
• Tag: Non
• Protein length: 1-457

Gene Information

• Gene Name: FOXA2 forkhead box A2 [ Homo sapiens ]
• Official Symbol: FOXA2
• Synonyms: FOXA2; forkhead box A2; hepatocyte nuclear factor 3, beta , HNF3B; hepatocyte nuclear factor 3-beta
• Gene ID: 3170
• mRNA Refseq: NM_021784
• Protein Refseq: NP_068556
• MIM: 600288
• Uniprot ID: Q9Y261
• Chromosome Location: 20p11
• Pathway: Developmental Biology, organism-specific biosystem; FOXA transcription factor networks, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Heart Development, organism-specific biosystem
• Function: DNA bending activity; DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; SMAD binding; double-stranded DNA binding

Reviews

03/21/2023

FOXA2 has strong anti-fouling ability, which effectively avoids the problem of contamination in the experiment.

05/16/2022

It has good application performance in immunoassays, such as ELISA, western blotting, etc.

06/25/2021

This protein has good fluorescence and absorption properties.

Q&As

What are the future research directions for FOXA2?

Future research directions on FOXA2 include in-depth study of its molecular mechanisms in embryonic development and disease development, the development of targeted drugs targeting FOXA2, and the exploration of its application in regenerative medicine and tissue engineering.

How can the results of FOXA2 be used to advance medicine?

The results of FOXA2 research can be used to advance medicine, such as developing diagnostic and therapeutic strategies for developmental defects and tumors, exploring new drug targets, and improving existing treatment options. At the same time, these research results can also be applied to regenerative medicine and tissue engineering for the repair of damaged tissues and organs.

What are the molecules that interact with FOXA2?

Molecules that interact with FOXA2 include other transcription factors, co-activators, co-repressors, etc. These molecules, together with FOXA2, regulate the expression of downstream genes.

How can I study the features of FOXA2?

A variety of experimental methods can be used to study the function of FOXA2, including gene knockout, overexpression, chromatin immunoprecipitation (ChIP), reporter gene analysis, and more. These methods can help us gain insight into the role of FOXA2 in embryonic development and disease development.

Does FOXA2 have a function in embryonic development?

FOXA2 plays a key role in embryonic development and is involved in regulating processes such as endoderm formation, differentiation of the pancreas and lungs, and development of the digestive tract.

How do you assess the quality and reliability of research results for FOXA2?

Assessing the quality and reliability of scientific research results for FOXA2 requires the use of scientific methods and standards, including the rationality of experimental design, the accuracy of data processing, and the logic and reproducibility of conclusions. In addition, peer review and quality assessment of papers published in high-level academic journals are required.